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| http://purl.uniprot.org/citations/20620873 | http://www.w3.org/2000/01/rdf-schema#comment | "Ca(2+)-activated BK channels modulate neuronal activities, including spike frequency adaptation and synaptic transmission. Previous studies found that Ca(2+)-binding sites and the activation gate are spatially separated in the channel protein, but the mechanism by which Ca(2+) binding opens the gate over this distance remains unknown. By studying an Asp-to-Gly mutation (D434G) associated with human syndrome of generalized epilepsy and paroxysmal dyskinesia (GEPD), we show that a cytosolic motif immediately following the activation gate S6 helix, known as the AC region, mediates the allosteric coupling between Ca(2+) binding and channel opening. The GEPD mutation inside the AC region increases BK channel activity by enhancing this allosteric coupling. We found that Ca(2+) sensitivity is enhanced by increases in solution viscosity that reduce protein dynamics. The GEPD mutation alters such a response, suggesting that a less flexible AC region may be more effective in coupling Ca(2+) binding to channel opening."xsd:string |
| http://purl.uniprot.org/citations/20620873 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2010.05.009"xsd:string |
| http://purl.uniprot.org/citations/20620873 | http://purl.uniprot.org/core/author | "Shi J."xsd:string |
| http://purl.uniprot.org/citations/20620873 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/20620873 | http://purl.uniprot.org/core/author | "Zhang G."xsd:string |
| http://purl.uniprot.org/citations/20620873 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/20620873 | http://purl.uniprot.org/core/author | "Cui J."xsd:string |
| http://purl.uniprot.org/citations/20620873 | http://purl.uniprot.org/core/author | "Sept D."xsd:string |
| http://purl.uniprot.org/citations/20620873 | http://purl.uniprot.org/core/author | "Saxena A."xsd:string |
| http://purl.uniprot.org/citations/20620873 | http://purl.uniprot.org/core/author | "Krishnamoorthy G."xsd:string |
| http://purl.uniprot.org/citations/20620873 | http://purl.uniprot.org/core/author | "Delaloye K."xsd:string |
| http://purl.uniprot.org/citations/20620873 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20620873 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/20620873 | http://purl.uniprot.org/core/pages | "871-883"xsd:string |
| http://purl.uniprot.org/citations/20620873 | http://purl.uniprot.org/core/title | "An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing."xsd:string |
| http://purl.uniprot.org/citations/20620873 | http://purl.uniprot.org/core/volume | "66"xsd:string |
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