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| http://purl.uniprot.org/citations/20620953 | http://www.w3.org/2000/01/rdf-schema#comment | "The H4K16 acetyltransferase MOF plays a crucial role in dosage compensation in Drosophila but has additional, global functions. We compared the molecular context and effect of MOF in male and female flies, combining chromosome-wide mapping and transcriptome studies with analyses of defined reporter loci in transgenic flies. MOF distributes dynamically between two complexes, the dosage compensation complex and a complex containing MBD-R2, a global facilitator of transcription. These different targeting principles define the distribution of MOF between the X chromosome and autosomes and at transcription units with 5' or 3' enrichment. The male X chromosome differs from all other chromosomes in that H4K16 acetylation levels do not correlate with transcription output. The reconstitution of this phenomenon at a model locus revealed that the activation potential of MOF is constrained in male cells in the context of the DCC to arrive at the 2-fold activation of transcription characteristic of dosage compensation."xsd:string |
| http://purl.uniprot.org/citations/20620953 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2010.05.022"xsd:string |
| http://purl.uniprot.org/citations/20620953 | http://purl.uniprot.org/core/author | "Becker P.B."xsd:string |
| http://purl.uniprot.org/citations/20620953 | http://purl.uniprot.org/core/author | "Straub T."xsd:string |
| http://purl.uniprot.org/citations/20620953 | http://purl.uniprot.org/core/author | "Feller C."xsd:string |
| http://purl.uniprot.org/citations/20620953 | http://purl.uniprot.org/core/author | "Prestel M."xsd:string |
| http://purl.uniprot.org/citations/20620953 | http://purl.uniprot.org/core/author | "Mitlohner H."xsd:string |
| http://purl.uniprot.org/citations/20620953 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20620953 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/20620953 | http://purl.uniprot.org/core/pages | "815-826"xsd:string |
| http://purl.uniprot.org/citations/20620953 | http://purl.uniprot.org/core/title | "The activation potential of MOF is constrained for dosage compensation."xsd:string |
| http://purl.uniprot.org/citations/20620953 | http://purl.uniprot.org/core/volume | "38"xsd:string |
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