| http://purl.uniprot.org/citations/20626721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20626721 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic variants of the alcohol-metabolizing enzyme ADH4, located on chromosome 4q22-4q23, have been related to alcohol dependence (AD) risk in previous research. The aim of this association study in a large multicenter sample of alcohol-dependent individuals and controls is to confirm ADH4 single nucleotide polymorphism (SNP) and haplotype association with AD and relevant related phenotypes. One thousand, six hundred and twenty-two (1622) inpatient subjects and 1469 control subjects with DSM-IV. AD from four addiction treatment centres were included. Characteristics of AD and related phenotypes including alcohol withdrawal, Cloninger's type I and II and first ages of drinking, regular drinking and AD onset were obtained using standardized structured interviews. After subjects were genotyped for 2 ADH4 polymorphisms, single SNP case-control and haplotype analyses were conducted. Both variants--rs1800759 and rs1042364-- and the A-A and C-G haplotypes were significantly related to AD across samples. Furthermore, associations with AD-related phenotypes and subtypes revealed a potential protective influence of this haplotype. This study confirms the significant relationship of ADH4 variants with AD and related phenotypes. While the rs1800759 and rs1042364 A-A haplotype had a potential protective influence on the risk for several AD-related phenotypes, this effect is rather small compared to functional variants of other alcohol or acetaldehyde-metabolizing enzymes like ALDH2*2 or ADH1B*2."xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1369-1600.2010.00236.x"xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/author | "Bondy B."xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/author | "Samochowiec J."xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/author | "Rujescu D."xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/author | "Zill P."xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/author | "Debniak T."xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/author | "Wodarz N."xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/author | "Fehr C."xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/author | "Grzywacz A."xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/author | "Koller G."xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/author | "Preuss U.W."xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/author | "Soyka M."xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/author | "Wurst F.M."xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/author | "Ridinger M."xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/name | "Addict Biol"xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/pages | "323-333"xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/title | "Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study."xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/20626721 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20626721 |
| http://purl.uniprot.org/citations/20626721 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20626721 |
| http://purl.uniprot.org/uniprot/#_P08319-mappedCitation-20626721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20626721 |
| http://purl.uniprot.org/uniprot/#_V9HVX7-mappedCitation-20626721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20626721 |