| http://purl.uniprot.org/citations/20627101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20627101 | http://www.w3.org/2000/01/rdf-schema#comment | "The full-length pro-survival protein Mcl-1 predominantly resides on the outer membrane of mitochondria. Here, we identified a mitochondrial matrix-localized isoform of Mcl-1 that lacks 33 amino acid residues at the N-terminus which serve both as a mitochondrial targeting and processing signal. Ectopically-expressed Mcl-1 without the N-terminal 33 residues failed to enter the mitochondrial matrix but retained wt-like activities both for interaction with BH3-only proteins and anti-apoptosis. In contrast, the mitochondrial matrix-localized isoform failed to interact with BH3-only proteins and manifested an attenuated anti-apoptotic activity. This study reveals that import of Mcl-1 into the mitochondrial matrix results in the attenuation of Mcl-1's anti-apoptotic function."xsd:string |
| http://purl.uniprot.org/citations/20627101 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2010.07.013"xsd:string |
| http://purl.uniprot.org/citations/20627101 | http://purl.uniprot.org/core/author | "Huang C.R."xsd:string |
| http://purl.uniprot.org/citations/20627101 | http://purl.uniprot.org/core/author | "Yang-Yen H.F."xsd:string |
| http://purl.uniprot.org/citations/20627101 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20627101 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/20627101 | http://purl.uniprot.org/core/pages | "3323-3330"xsd:string |
| http://purl.uniprot.org/citations/20627101 | http://purl.uniprot.org/core/title | "The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity."xsd:string |
| http://purl.uniprot.org/citations/20627101 | http://purl.uniprot.org/core/volume | "584"xsd:string |
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| http://purl.uniprot.org/citations/20627101 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20627101 |
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| http://purl.uniprot.org/uniprot/#_A0A494BAU0-mappedCitation-20627101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20627101 |
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| http://purl.uniprot.org/uniprot/#_P00395-mappedCitation-20627101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20627101 |
| http://purl.uniprot.org/uniprot/#_O94826-mappedCitation-20627101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20627101 |
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| http://purl.uniprot.org/uniprot/#_P97287-mappedCitation-20627101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20627101 |