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http://purl.uniprot.org/citations/20627339http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20627339http://www.w3.org/2000/01/rdf-schema#comment"

Background

Recently, concerns have been raised about a possible lack of sensitivity of biomarkers to detect left ventricular (LV) dysfunction in patients with myopathies. We examined the ability of the N-terminal brain natriuretic peptide (NT-proBNP) to detect LV or right ventricular (RV) dysfunction in patients with lamin A/C (LMNA) gene mutations.

Methods

We prospectively measured plasma NT-proBNP in consecutive patients with documented LMNA mutations and age-sex matched controls. All patients underwent standard echocardiography implemented by pulsed tissue-Doppler echocardiography (TDE).

Results

Twenty-three patients were included (10 males, mean age 39.2 ± 18.9 years);10 had previous atrial arrhythmias, 8 had been implanted with cardioverter defibrillator for primary prevention of sudden death, 5 patients were of NYHA class II and 18 of NHYA class I. Sinus rhythm was recorded in all. NT-proBNP was increased in LMNA patients versus controls (123 ± 229 versus 26 ± 78 pg/ml, p=0.0004); 7 patients had depressed LV and/or RV contractility. Patients with reduced LV or RV contractility had increased mean NT-proBNP (341 ± 1032 pg/ml versus 80 ± 79 pg/ml in patients with normal myocardial contractility, p=0.004). Receiver-operating-characteristics analysis shows that NT-proBNP reliably detected depressed contractility (area under the curve 0.889 [0.697-1.000]). Sensitivity and specificity were 88% and 83% respectively, applying manufacturer's recommended cut-off concentration of 125 pg/ml.

Conclusion

NT-proBNP reliably detected the presence of reduced LV/RV contractility in LMNA patients."xsd:string
http://purl.uniprot.org/citations/20627339http://purl.org/dc/terms/identifier"doi:10.1016/j.ijcard.2010.05.005"xsd:string
http://purl.uniprot.org/citations/20627339http://purl.uniprot.org/core/author"Bonne G."xsd:string
http://purl.uniprot.org/citations/20627339http://purl.uniprot.org/core/author"Wahbi K."xsd:string
http://purl.uniprot.org/citations/20627339http://purl.uniprot.org/core/author"Duboc D."xsd:string
http://purl.uniprot.org/citations/20627339http://purl.uniprot.org/core/author"Pecker F."xsd:string
http://purl.uniprot.org/citations/20627339http://purl.uniprot.org/core/author"Gobeaux C."xsd:string
http://purl.uniprot.org/citations/20627339http://purl.uniprot.org/core/author"Meune C."xsd:string
http://purl.uniprot.org/citations/20627339http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/20627339http://purl.uniprot.org/core/name"Int J Cardiol"xsd:string
http://purl.uniprot.org/citations/20627339http://purl.uniprot.org/core/pages"160-163"xsd:string
http://purl.uniprot.org/citations/20627339http://purl.uniprot.org/core/title"N-terminal Pro brain natriuretic peptide is a reliable biomarker of reduced myocardial contractility in patients with lamin A/C gene mutations."xsd:string
http://purl.uniprot.org/citations/20627339http://purl.uniprot.org/core/volume"151"xsd:string
http://purl.uniprot.org/citations/20627339http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20627339
http://purl.uniprot.org/citations/20627339http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20627339
http://purl.uniprot.org/uniprot/#_A0A384MQX1-mappedCitation-20627339http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20627339
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http://purl.uniprot.org/uniprot/#_Q8N519-mappedCitation-20627339http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20627339
http://purl.uniprot.org/uniprot/#_P02545-mappedCitation-20627339http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20627339
http://purl.uniprot.org/uniprot/#_Q5I6Y5-mappedCitation-20627339http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20627339
http://purl.uniprot.org/uniprot/#_Q5TCI8-mappedCitation-20627339http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20627339
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http://purl.uniprot.org/uniprot/#_W8QEH3-mappedCitation-20627339http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20627339
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