| http://purl.uniprot.org/citations/20628268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20628268 | http://www.w3.org/2000/01/rdf-schema#comment | "Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints. Transforming growth factor-beta1 (TGF-beta1) is a secreted protein that promotes differentiation of synovial fibroblasts to alpha-smooth muscle actin (alpha-SMA)-positive myofibroblasts to repair the damaged joints. Synovial fluid from patients with RA (RA-SF) induced expression of alpha-SMA in human adipose tissue-derived mesenchymal stem cells (hASCs). RA-SF-induced alpha-SMA expression was abrogated by immunodepletion of TGF-beta1 from RA-SF with anti-TGF-beta1 antibody. Furthermore, pretreatment of hASCs with the TGF-beta type I receptor inhibitor SB431542 or lentiviral small hairpin RNA-mediated silencing of TGF-beta type I receptor expression in hASCs blocked RA-SF-induced alpha-SMA expression. Small interfering RNA-mediated silencing of Smad2 or adenoviral overexpression of Smad7 (an inhibitory Smad isoform) completely inhibited RA-SF-stimulated alpha-SMA expression. These results suggest that TGF-beta1 plays a pivotal role in RA-SF-induced differentiation of hASCs to alpha-SMA-positive cells."xsd:string |
| http://purl.uniprot.org/citations/20628268 | http://purl.org/dc/terms/identifier | "doi:10.3858/emm.2010.42.8.057"xsd:string |
| http://purl.uniprot.org/citations/20628268 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/20628268 | http://purl.uniprot.org/core/author | "Lee J.S."xsd:string |
| http://purl.uniprot.org/citations/20628268 | http://purl.uniprot.org/core/author | "Kim K.H."xsd:string |
| http://purl.uniprot.org/citations/20628268 | http://purl.uniprot.org/core/author | "Kim M.Y."xsd:string |
| http://purl.uniprot.org/citations/20628268 | http://purl.uniprot.org/core/author | "Lee I.H."xsd:string |
| http://purl.uniprot.org/citations/20628268 | http://purl.uniprot.org/core/author | "Shin S.H."xsd:string |
| http://purl.uniprot.org/citations/20628268 | http://purl.uniprot.org/core/author | "Song H.Y."xsd:string |
| http://purl.uniprot.org/citations/20628268 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20628268 | http://purl.uniprot.org/core/name | "Exp Mol Med"xsd:string |
| http://purl.uniprot.org/citations/20628268 | http://purl.uniprot.org/core/pages | "565-573"xsd:string |
| http://purl.uniprot.org/citations/20628268 | http://purl.uniprot.org/core/title | "Synovial fluid of patients with rheumatoid arthritis induces alpha-smooth muscle actin in human adipose tissue-derived mesenchymal stem cells through a TGF-beta1-dependent mechanism."xsd:string |
| http://purl.uniprot.org/citations/20628268 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/20628268 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20628268 |
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