| http://purl.uniprot.org/citations/20628391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20628391 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundThe impact of thymidylate synthase (TYMS) and UDP-glucoronosyltransferase 1A (UGT1A) germline polymorphisms on the outcome of colorectal cancer (CRC) patients treated with irinotecan plus 5-fluorouracil (irinotecan/5FU) is still controversial. Our objective was to define a genetic-based algorithm to select patients to be treated with irinotecan/5FU.MethodsGenotyping of TYMS (5'TRP and 3'UTR), UGT1A1(*)28, UGT1A9(*)22 and UGT1A7(*)3 was performed in 149 metastatic CRC patients treated with irinotecan/5FU as first-line chemotherapy enrolled in a randomised phase 3 study. Their association with response, toxicity and survival was investigated by univariate and multivariate statistical analysis.ResultsTYMS 3TRP/3TRP genotype was the only independent predictor of tumour response (OR=5.87, 95% confidence interval (CI)=1.68-20.45; P=0.005). UGT1A1(*)28/(*)28 was predictive for haematologic toxicity (OR=6.27, 95% CI=1.09-36.12; P=0.04), specifically for neutropenia alone (OR=6.40, 95% CI=1.11-37.03; P=0.038) or together with diarrhoea (OR=18.87, 95% CI=2.14-166.67; P=0.008). UGT1A9(*)1/(*)1 was associated with non-haematologic toxicity (OR=2.70, 95% CI=1.07-6.82; P=0.035). Haplotype VII (all non-favourable alleles) was associated with non-haematologic toxicity (OR=2.11, 95% CI=1.12-3.98; P=0.02).ConclusionTYMS and UGT1A polymorphisms influence on tumour response and toxicities derived from irinotecan/5FU treatment in CRC patients. A genetic-based algorithm to optimise treatment individualisation is proposed."xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.bjc.6605776"xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/author | "Navarro M."xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/author | "Aranda E."xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/author | "Abad A."xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/author | "Moreno V."xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/author | "Benavides M."xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/author | "Martinez-Cardus A."xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/author | "Carrato A."xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/author | "Manzano J.L."xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/author | "Martinez-Balibrea E."xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/author | "Massuti B."xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/author | "Marcuello E."xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/author | "Valladares M."xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/author | "Gines A."xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/author | "Layos L."xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/name | "Br J Cancer"xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/pages | "581-589"xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/title | "UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy."xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/20628391 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20628391 |
| http://purl.uniprot.org/citations/20628391 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20628391 |
| http://purl.uniprot.org/uniprot/#_A0A1L2FNL9-mappedCitation-20628391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20628391 |