| http://purl.uniprot.org/citations/2063194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2063194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2063194 | http://www.w3.org/2000/01/rdf-schema#comment | "Human apolipoprotein E, a blood plasma protein, mediates the transport and uptake of cholesterol and lipid by way of its high affinity interaction with different cellular receptors, including the low-density lipoprotein (LDL) receptor. The three-dimensional structure of the LDL receptor-binding domain of apoE has been determined at 2.5 angstrom resolution by x-ray crystallography. The protein forms an unusually elongated (65 angstroms) four-helix bundle, with the helices apparently stabilized by a tightly packed hydrophobic core that includes leucine zipper-type interactions and by numerous salt bridges on the mostly charged surface. Basic amino acids important for LDL receptor binding are clustered into a surface patch on one long helix. This structure provides the basis for understanding the behavior of naturally occurring mutants that can lead to atherosclerosis."xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.2063194"xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.2063194"xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/author | "Agard D.A."xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/author | "Agard D.A."xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/author | "Wilson C."xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/author | "Wilson C."xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/author | "Wardell M.R."xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/author | "Wardell M.R."xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/author | "Mahley R.W."xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/author | "Mahley R.W."xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/author | "Weisgraber K.H."xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/author | "Weisgraber K.H."xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/pages | "1817-1822"xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/pages | "1817-1822"xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/title | "Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E."xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/title | "Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E."xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/volume | "252"xsd:string |
| http://purl.uniprot.org/citations/2063194 | http://purl.uniprot.org/core/volume | "252"xsd:string |