| http://purl.uniprot.org/citations/20637286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20637286 | http://www.w3.org/2000/01/rdf-schema#comment | "The apurinic/apyrimidinic endonuclease/redox effector factor-1 (APE/Ref-1) is involved in the base excision repair of apurinic/apyrimidinic sites induced by oxidative DNA damage. APE/Ref-1 was decreased by kainic acid (KA) injury in a time-dependent manner at the level of proteins, not transcripts. We investigated whether alteration of APE/Ref-1 amounts would influence hippocampal cell fate, survival or death, after KA injury. Overexpression of APE/Ref-1 using adenovirus and restoration of APE small peptides significantly reduced KA-induced hippocampal cell death. Both silencing of APE/Ref-1 by siRNA and inhibition of endonuclease by an antibody significantly increased caspase-3 activity and apoptotic cell death triggered from the early time after exposure to KA. These findings suggest that cell death is initiated by reducing APE/Ref-1 protein and inhibiting its repair function in spite of enough protein amounts. In conclusion, APE/Ref-1 may be a regulator of cell death initiation, and APE small peptides could provide molecular mechanism-based therapies for neuroprotection in progressive excitotoxic neuronal damage."xsd:string |
| http://purl.uniprot.org/citations/20637286 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mcn.2010.07.001"xsd:string |
| http://purl.uniprot.org/citations/20637286 | http://purl.uniprot.org/core/author | "Kim H.J."xsd:string |
| http://purl.uniprot.org/citations/20637286 | http://purl.uniprot.org/core/author | "Park S.C."xsd:string |
| http://purl.uniprot.org/citations/20637286 | http://purl.uniprot.org/core/author | "Kim H.W."xsd:string |
| http://purl.uniprot.org/citations/20637286 | http://purl.uniprot.org/core/author | "Kim G.W."xsd:string |
| http://purl.uniprot.org/citations/20637286 | http://purl.uniprot.org/core/author | "Cho K.J."xsd:string |
| http://purl.uniprot.org/citations/20637286 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20637286 | http://purl.uniprot.org/core/name | "Mol Cell Neurosci"xsd:string |
| http://purl.uniprot.org/citations/20637286 | http://purl.uniprot.org/core/pages | "267-276"xsd:string |
| http://purl.uniprot.org/citations/20637286 | http://purl.uniprot.org/core/title | "Decisive role of apurinic/apyrimidinic endonuclease/Ref-1 in initiation of cell death."xsd:string |
| http://purl.uniprot.org/citations/20637286 | http://purl.uniprot.org/core/volume | "45"xsd:string |
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