| http://purl.uniprot.org/citations/20639394 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20639394 | http://www.w3.org/2000/01/rdf-schema#comment | "A large-scale, genome-wide association study was performed to identify genetic variations influencing serum bilirubin levels using 8841 Korean individuals. Significant associations were observed at UGT1A1 (rs11891311, P = 4.78 x 10(-148)) and SLCO1B3 (rs2417940, P = 1.03 x 10(-17)), which are two previously identified loci. The two single-nucleotide polymorphisms (SNPs) were replicated (rs11891311, P = 3.18 x 10(-15)) or marginally significant (rs2417940, P = 8.56 x 10(-4)) in an independent cohort of 1096 individuals. In a conditional analysis adjusted for the top UGT1A1 variant (rs11891311), another variant in UGT1A1 (rs4148323, P = 1.22 x 10(-121)) remained significant; this suggests that in UGT1A1 at least two independent genetic variations influence the bilirubin levels in the Korean population. The protein coding variant rs4148323, which is monomorphic in European-derived populations, may be specifically associated with serum bilirubin levels in Asians (P = 2.56 x 10(-70)). The SLCO1B3 variant (rs2417940, P = 1.67 x 10(-18)) remained significant in a conditional analysis for the top UGT1A1 variant. Interestingly, there were significant differences in the associated variations of SLCO1B3 between Koreans and European-derived populations. While the variant rs2417940 at intron 7 of SLCO1B3 was more significantly associated in Koreans, variants rs17680137 (P = 0.584) and rs2117032 (P = 2.76 x 10(-5)), two of the top-ranked SNPs in European-derived populations, did not reach the genome-wide significance level. Also, variants in SLCO1B1 did not reach genome-wide significance in Koreans. Our result supports the idea that there are considerable ethnic differences in genetic association of bilirubin levels between Koreans and European-derived populations."xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddq281"xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://purl.uniprot.org/core/author | "Kim K.K."xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://purl.uniprot.org/core/author | "Kim J.W."xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://purl.uniprot.org/core/author | "Kim Y.S."xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://purl.uniprot.org/core/author | "Kim H.J."xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://purl.uniprot.org/core/author | "Kim S.Y."xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://purl.uniprot.org/core/author | "Kim J.Y."xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://purl.uniprot.org/core/author | "Lee H.C."xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://purl.uniprot.org/core/author | "Ju H."xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://purl.uniprot.org/core/author | "Jeon Y.J."xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://purl.uniprot.org/core/author | "Kang T.W."xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20639394 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://purl.uniprot.org/core/pages | "3672-3678"xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://purl.uniprot.org/core/title | "Genome-wide association of serum bilirubin levels in Korean population."xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/20639394 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20639394 |
| http://purl.uniprot.org/citations/20639394 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20639394 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YYJ9-mappedCitation-20639394 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20639394 |
| http://purl.uniprot.org/uniprot/#_A0A1L2FNL9-mappedCitation-20639394 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20639394 |
| http://purl.uniprot.org/uniprot/#_A0A0M4UT75-mappedCitation-20639394 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20639394 |