| http://purl.uniprot.org/citations/20639454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20639454 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor-associated antigens, which induce the generation of autoantibodies, are useful as cancer biomarkers in early detection and prognostic prediction of cancer. To isolate a novel cancer marker, we used serum antibodies from colon cancer patients to screen a phage display peptide library. A positive peptide 249C (VPLYSNTLRYGF) that could specifically react with serum from colon cancer patients was isolated, and the corresponding antigen-human arrest defective 1 (ARD1A), which shares an identical LYSNTL motif with 249C, was identified. Both immunological assays and three-dimensional structure analysis showed that the LYSNTL region is an epitope of ARD1A. Using ELISA and immunohistochemistry, we found anti-ARD1A antibody levels in serum from patients with colon cancer were significantly higher than those in healthy volunteers (P < 0.001), and ARD1A expression was detected in 84.1% (227/270) of colon cancer tissues compared with 22.7% (55/242) of matched noncancerous tissues (P < 0.001) and 4.8% (2/42) of benign lesions (P < 0.001). Furthermore, multivariate analysis with Cox proportional hazards regression models revealed that ARD1A-positive patients had significantly shortened overall survival (OS) (HR, 1.91, P = 0.039) and borderline significantly shortened disease-free survival (DFS) (HR, 1.70; P = 0.068). Kaplan-Meier survival curves also showed that ARD1A expression was associated significantly with shortened DFS (P = 0.037) and OS (P = 0.019). These results indicate that ARD1A is a novel tumor-associated antigen and a potential prognostic factor for colon cancer."xsd:string |
| http://purl.uniprot.org/citations/20639454 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2010.091178"xsd:string |
| http://purl.uniprot.org/citations/20639454 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/20639454 | http://purl.uniprot.org/core/author | "Jiang B."xsd:string |
| http://purl.uniprot.org/citations/20639454 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/20639454 | http://purl.uniprot.org/core/author | "Dong B."xsd:string |
| http://purl.uniprot.org/citations/20639454 | http://purl.uniprot.org/core/author | "Qu L."xsd:string |
| http://purl.uniprot.org/citations/20639454 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/20639454 | http://purl.uniprot.org/core/author | "Ren T."xsd:string |
| http://purl.uniprot.org/citations/20639454 | http://purl.uniprot.org/core/author | "Meng L."xsd:string |
| http://purl.uniprot.org/citations/20639454 | http://purl.uniprot.org/core/author | "Jin G."xsd:string |
| http://purl.uniprot.org/citations/20639454 | http://purl.uniprot.org/core/author | "Qu H."xsd:string |
| http://purl.uniprot.org/citations/20639454 | http://purl.uniprot.org/core/author | "Shou C."xsd:string |
| http://purl.uniprot.org/citations/20639454 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20639454 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/20639454 | http://purl.uniprot.org/core/pages | "1095-1103"xsd:string |
| http://purl.uniprot.org/citations/20639454 | http://purl.uniprot.org/core/title | "Peptide mimic isolated by autoantibody reveals human arrest defective 1 overexpression is associated with poor prognosis for colon cancer patients."xsd:string |
| http://purl.uniprot.org/citations/20639454 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/20639454 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20639454 |
| http://purl.uniprot.org/citations/20639454 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20639454 |
| http://purl.uniprot.org/uniprot/#_B4DFG1-mappedCitation-20639454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20639454 |
| http://purl.uniprot.org/uniprot/#_B4DKJ7-mappedCitation-20639454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20639454 |
| http://purl.uniprot.org/uniprot/#_B7Z9N2-mappedCitation-20639454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20639454 |
| http://purl.uniprot.org/uniprot/#_P41227-mappedCitation-20639454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20639454 |