| http://purl.uniprot.org/citations/20639485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20639485 | http://www.w3.org/2000/01/rdf-schema#comment | "The TNF superfamily members CD70 and OX40 ligand (OX40L) were reported to be important for CD4(+) T cell expansion and differentiation. However, the relative contribution of these costimulatory signals in driving CD4(+) T cell responses has not been addressed. In this study, we found that OX40L is a more important determinant than CD70 of the primary CD4(+) T cell response to multiple immunization regimens. Despite the ability of a combined TLR and CD40 agonist (TLR/CD40) stimulus to provoke appreciable expression of CD70 and OX40L on CD8(+) dendritic cells, resulting CD4(+) T cell responses were substantially reduced by Ab blockade of OX40L and, to a lesser degree, CD70. In contrast, the CD8(+) T cell responses to combined TLR/CD40 immunization were exclusively dependent on CD70. These requirements for CD4(+) and CD8(+) T cell activation were not limited to the use of combined TLR/CD40 immunization, because vaccinia virus challenge elicited primarily OX40L-dependent CD4 responses and exclusively CD70-dependent CD8(+) T cell responses. Attenuation of CD4(+) T cell priming induced by OX40L blockade was independent of signaling through the IL-12R, but it was reduced further by coblockade of CD70. Thus, costimulation by CD70 or OX40L seems to be necessary for primary CD4(+) T cell responses to multiple forms of immunization, and each may make independent contributions to CD4(+) T cell priming."xsd:string |
| http://purl.uniprot.org/citations/20639485 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1000172"xsd:string |
| http://purl.uniprot.org/citations/20639485 | http://purl.uniprot.org/core/author | "Kedl R.M."xsd:string |
| http://purl.uniprot.org/citations/20639485 | http://purl.uniprot.org/core/author | "Sanchez P.J."xsd:string |
| http://purl.uniprot.org/citations/20639485 | http://purl.uniprot.org/core/author | "Burchill M.A."xsd:string |
| http://purl.uniprot.org/citations/20639485 | http://purl.uniprot.org/core/author | "Haluszczak C."xsd:string |
| http://purl.uniprot.org/citations/20639485 | http://purl.uniprot.org/core/author | "Kurche J.S."xsd:string |
| http://purl.uniprot.org/citations/20639485 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20639485 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20639485 | http://purl.uniprot.org/core/pages | "2106-2115"xsd:string |
| http://purl.uniprot.org/citations/20639485 | http://purl.uniprot.org/core/title | "Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responses."xsd:string |
| http://purl.uniprot.org/citations/20639485 | http://purl.uniprot.org/core/volume | "185"xsd:string |
| http://purl.uniprot.org/citations/20639485 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20639485 |
| http://purl.uniprot.org/citations/20639485 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20639485 |
| http://purl.uniprot.org/uniprot/P43488#attribution-20BE07828040C9D7E7E183A7F6416AA7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20639485 |
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| http://purl.uniprot.org/uniprot/#_B6DXE3-mappedCitation-20639485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20639485 |
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| http://purl.uniprot.org/uniprot/#_O55237-mappedCitation-20639485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20639485 |
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| http://purl.uniprot.org/uniprot/#_P27512-mappedCitation-20639485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20639485 |
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| http://purl.uniprot.org/uniprot/#_P97378-mappedCitation-20639485 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20639485 |