| http://purl.uniprot.org/citations/20641039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20641039 | http://www.w3.org/2000/01/rdf-schema#comment | "Zeta-chain-associated protein kinase-70 (Zap70), a Syk family tyrosine kinase, has been reported to be present exclusively in normal T-cells, natural killer cells, and B cells, serving as a pivotal regulator of antigen-mediated receptor signaling and development. In this study, we report that Zap70 is expressed in undifferentiated mouse embryonic stem cells (mESCs) and may critically regulate self-renewal and pluripotency in mESCs. We found that Zap70 knocked-down mESCs (Zap70KD) show sustained self-renewal and defective differentiation. In addition, we present evidence that the sustained self-renewal in Zap70KD is associated with enhanced Jak/Stat3 signaling and c-Myc induction. These altered signaling appears to result from upregulated leukemia inhibitory factor receptor and downregulated src homology region 2 domain containing phosphatase 1 (SHP-1) phosphatase activity. On the basis of these results, we propose that in undifferentiated mESCs, Zap70 plays important roles in modulating the balance between self-renewal capacity and pluripotent differentiation ability as a key regulator of the Jak/Stat3/c-Myc signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/20641039 | http://purl.org/dc/terms/identifier | "doi:10.1002/stem.470"xsd:string |
| http://purl.uniprot.org/citations/20641039 | http://purl.uniprot.org/core/author | "Kim K.S."xsd:string |
| http://purl.uniprot.org/citations/20641039 | http://purl.uniprot.org/core/author | "Lee K.A."xsd:string |
| http://purl.uniprot.org/citations/20641039 | http://purl.uniprot.org/core/author | "Ahn H.J."xsd:string |
| http://purl.uniprot.org/citations/20641039 | http://purl.uniprot.org/core/author | "Park K.S."xsd:string |
| http://purl.uniprot.org/citations/20641039 | http://purl.uniprot.org/core/author | "Lee H.J."xsd:string |
| http://purl.uniprot.org/citations/20641039 | http://purl.uniprot.org/core/author | "Cha H.J."xsd:string |
| http://purl.uniprot.org/citations/20641039 | http://purl.uniprot.org/core/author | "Lee M.O."xsd:string |
| http://purl.uniprot.org/citations/20641039 | http://purl.uniprot.org/core/author | "Fornace A.J. Jr."xsd:string |
| http://purl.uniprot.org/citations/20641039 | http://purl.uniprot.org/core/author | "Cha Y."xsd:string |
| http://purl.uniprot.org/citations/20641039 | http://purl.uniprot.org/core/author | "Moon B.H."xsd:string |
| http://purl.uniprot.org/citations/20641039 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20641039 | http://purl.uniprot.org/core/name | "Stem Cells"xsd:string |
| http://purl.uniprot.org/citations/20641039 | http://purl.uniprot.org/core/pages | "1476-1486"xsd:string |
| http://purl.uniprot.org/citations/20641039 | http://purl.uniprot.org/core/title | "Zap70 functions to maintain stemness of mouse embryonic stem cells by negatively regulating Jak1/Stat3/c-Myc signaling."xsd:string |
| http://purl.uniprot.org/citations/20641039 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/20641039 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20641039 |
| http://purl.uniprot.org/citations/20641039 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20641039 |
| http://purl.uniprot.org/uniprot/#_B1ASP2-mappedCitation-20641039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20641039 |
| http://purl.uniprot.org/uniprot/#_O88594-mappedCitation-20641039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20641039 |
| http://purl.uniprot.org/uniprot/#_P52332-mappedCitation-20641039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20641039 |
| http://purl.uniprot.org/uniprot/#_Q3TI10-mappedCitation-20641039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20641039 |
| http://purl.uniprot.org/uniprot/#_Q3U8P8-mappedCitation-20641039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20641039 |