| http://purl.uniprot.org/citations/20643337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20643337 | http://www.w3.org/2000/01/rdf-schema#comment | "Distal cis-regulatory elements play essential roles in the T lineage-specific expression of cytokine genes. We have mapped interactions of three trans-acting factors-NF-kappaB, STAT4, and T-bet-with cis elements in the Ifng locus. We find that RelA is critical for optimal Ifng expression and is differentially recruited to multiple elements contingent upon T cell receptor (TCR) or interleukin-12 (IL-12) plus IL-18 signaling. RelA recruitment to at least four elements is dependent on T-bet-dependent remodeling of the Ifng locus and corecruitment of STAT4. STAT4 and NF-kappaB therefore cooperate at multiple cis elements to enable NF-kappaB-dependent enhancement of Ifng expression. RelA recruitment to distal elements was similar in T helper 1 (Th1) and effector CD8(+) T (Tc1) cells, although T-bet was dispensable in CD8 effectors. These results support a model of Ifng regulation in which distal cis-regulatory elements differentially recruit key transcription factors in a modular fashion to initiate gene transcription induced by distinct activation signals."xsd:string |
| http://purl.uniprot.org/citations/20643337 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2010.07.004"xsd:string |
| http://purl.uniprot.org/citations/20643337 | http://purl.uniprot.org/core/author | "Shibata Y."xsd:string |
| http://purl.uniprot.org/citations/20643337 | http://purl.uniprot.org/core/author | "Hatton R.D."xsd:string |
| http://purl.uniprot.org/citations/20643337 | http://purl.uniprot.org/core/author | "Crawford G.E."xsd:string |
| http://purl.uniprot.org/citations/20643337 | http://purl.uniprot.org/core/author | "Baldwin A.S."xsd:string |
| http://purl.uniprot.org/citations/20643337 | http://purl.uniprot.org/core/author | "Weaver C.T."xsd:string |
| http://purl.uniprot.org/citations/20643337 | http://purl.uniprot.org/core/author | "Balasubramani A."xsd:string |
| http://purl.uniprot.org/citations/20643337 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20643337 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/20643337 | http://purl.uniprot.org/core/pages | "35-47"xsd:string |
| http://purl.uniprot.org/citations/20643337 | http://purl.uniprot.org/core/title | "Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli."xsd:string |
| http://purl.uniprot.org/citations/20643337 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/20643337 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20643337 |
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