| http://purl.uniprot.org/citations/20647008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20647008 | http://www.w3.org/2000/01/rdf-schema#comment | "Although internal ribosome entry site (IRES)-mediated translation is considered important for proper cellular function, its precise biological role is not fully understood. Runx1 gene, which encodes a transcription factor implicated in hematopoiesis, angiogenesis, and leukemogenesis, contains IRES sequences in the 5' untranslated region. To clarify the roles of the IRES element in Runx1 function, we generated knock-in mice for either wild-type Runx1 or Runx1/Evi1, a Runx1 fusion protein identified in human leukemia. In both cases, native promoter-dependent transcription was retained, whereas IRES-mediated translation was eliminated. Interestingly, homozygotes expressing wild-type Runx1 deleted for the IRES element (Runx1(Delta IRES/Delta IRES)) died in utero with prominent dilatation of peripheral blood vessels due to impaired pericyte development. In addition, hematopoietic cells in the Runx1(Delta IRES/Delta IRES) fetal liver were significantly decreased, and exhibited an altered differentiation pattern, a reduced proliferative activity, and an impaired reconstitution ability. On the other hand, heterozygotes expressing Runx1/Evi1 deleted for the IRES element (Runx1(+/RE Delta IRES)) were born normally and did not show any hematological abnormalities, in contrast that conventional Runx1/Evi1 heterozygotes die in utero with central nervous system hemorrhage and Runx1/Evi1 chimeric mice develop acute leukemia. The findings reported here demonstrate the essential roles of the IRES element in Runx1 function under physiological and pathological conditions."xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2010.07.015"xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://purl.uniprot.org/core/author | "Tsuji K."xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://purl.uniprot.org/core/author | "Oda H."xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://purl.uniprot.org/core/author | "Miyazaki K."xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://purl.uniprot.org/core/author | "Ma F."xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://purl.uniprot.org/core/author | "Okuda T."xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://purl.uniprot.org/core/author | "Yamasaki N."xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://purl.uniprot.org/core/author | "Inaba T."xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://purl.uniprot.org/core/author | "Kanno M."xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://purl.uniprot.org/core/author | "Honda H."xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://purl.uniprot.org/core/author | "Nagamachi A."xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://purl.uniprot.org/core/author | "Honda Z."xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://purl.uniprot.org/core/author | "Htun P.W."xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20647008 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://purl.uniprot.org/core/pages | "226-236"xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://purl.uniprot.org/core/title | "A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model."xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://purl.uniprot.org/core/volume | "345"xsd:string |
| http://purl.uniprot.org/citations/20647008 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20647008 |
| http://purl.uniprot.org/citations/20647008 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20647008 |
| http://purl.uniprot.org/uniprot/#_A0A087WPL0-mappedCitation-20647008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20647008 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQL9-mappedCitation-20647008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20647008 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0Y5-mappedCitation-20647008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20647008 |