| http://purl.uniprot.org/citations/20647424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20647424 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20647424 | http://www.w3.org/2000/01/rdf-schema#comment | "African Americans have higher rates of kidney disease than European Americans. Here, we show that, in African Americans, focal segmental glomerulosclerosis (FSGS) and hypertension-attributed end-stage kidney disease (H-ESKD) are associated with two independent sequence variants in the APOL1 gene on chromosome 22 {FSGS odds ratio = 10.5 [95% confidence interval (CI) 6.0 to 18.4]; H-ESKD odds ratio = 7.3 (95% CI 5.6 to 9.5)}. The two APOL1 variants are common in African chromosomes but absent from European chromosomes, and both reside within haplotypes that harbor signatures of positive selection. ApoL1 (apolipoprotein L-1) is a serum factor that lyses trypanosomes. In vitro assays revealed that only the kidney disease-associated ApoL1 variants lysed Trypanosoma brucei rhodesiense. We speculate that evolution of a critical survival factor in Africa may have contributed to the high rates of renal disease in African Americans."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1193032"xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1193032"xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Pays E."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Pays E."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Lecordier L."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Lecordier L."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Genovese G."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Genovese G."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Pollak M.R."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Pollak M.R."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Kopp J.B."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Kopp J.B."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Vanhollebeke B."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Vanhollebeke B."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Oleksyk T.K."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Oleksyk T.K."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Bernhardy A.J."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Bernhardy A.J."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Bowden D.W."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Bowden D.W."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Freedman B.I."xsd:string |
| http://purl.uniprot.org/citations/20647424 | http://purl.uniprot.org/core/author | "Freedman B.I."xsd:string |