| http://purl.uniprot.org/citations/20647560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20647560 | http://www.w3.org/2000/01/rdf-schema#comment | "Engagement of 2B4 (CD244) with CD48 results in activation, costimulation, or inhibition of NK cell activities, depending on the cell types and the stage of differentiation. In vivo, 2B4+ NK cells can interact with CD48+ NK cells and also with surrounding CD48+ hematopoietic cells. Similarly, CD48+ NK cells may be triggered by adjacent 2B4+ NK cells or other hematopoietic cells expressing 2B4, e.g., monocytes, basophils, γδ T cells, etc. As CD48 was also shown to function as an activating receptor, 2B4/CD48 binding in the settings of NK-to-NK or NK-to-non-NK cell interactions may generate bidirectional signals. To address this question, we examined the consequence of CD48 or 2B4 ligation using two experimental settings: one with target (syngeneic EL4 and allogeneic P815) cells, ectopically expressing surface 2B4 or CD48, and the other with direct cross-linking with plate-bound mAb. Here, we report that ligation of CD48 with 2B4+ EL4 or 2B4+ P815 targets, in the absence of other receptor engagement, did not alter NK cell cytotoxicity or proliferation significantly. Similarly, cross-linking of NK cells with plate-bound anti-CD48 mAb in the absence or presence of a suboptimal dose of IL-2 did not modulate NK proliferation, cytotoxicity, or cytokine production. Nonetheless, 2B4 cross-linking promoted NK cell proliferation and effector functions consistently in both settings. Therefore, our results demonstrate unequivocally that CD48 on surrounding NK or non-NK cells serves primarily as a ligand to stimulate 2B4 on the adjacent NK cells in mice."xsd:string |
| http://purl.uniprot.org/citations/20647560 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.0410198"xsd:string |
| http://purl.uniprot.org/citations/20647560 | http://purl.uniprot.org/core/author | "Kim K."xsd:string |
| http://purl.uniprot.org/citations/20647560 | http://purl.uniprot.org/core/author | "Kim T.J."xsd:string |
| http://purl.uniprot.org/citations/20647560 | http://purl.uniprot.org/core/author | "Kim T.W."xsd:string |
| http://purl.uniprot.org/citations/20647560 | http://purl.uniprot.org/core/author | "Kim N."xsd:string |
| http://purl.uniprot.org/citations/20647560 | http://purl.uniprot.org/core/author | "Kumar V."xsd:string |
| http://purl.uniprot.org/citations/20647560 | http://purl.uniprot.org/core/author | "Lee K.M."xsd:string |
| http://purl.uniprot.org/citations/20647560 | http://purl.uniprot.org/core/author | "Kim E.O."xsd:string |
| http://purl.uniprot.org/citations/20647560 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20647560 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/20647560 | http://purl.uniprot.org/core/pages | "707-714"xsd:string |
| http://purl.uniprot.org/citations/20647560 | http://purl.uniprot.org/core/title | "Unidirectional signaling triggered through 2B4 (CD244), not CD48, in murine NK cells."xsd:string |
| http://purl.uniprot.org/citations/20647560 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/20647560 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20647560 |
| http://purl.uniprot.org/citations/20647560 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20647560 |
| http://purl.uniprot.org/uniprot/#_Q07763-mappedCitation-20647560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20647560 |
| http://purl.uniprot.org/uniprot/#_F8WHM0-mappedCitation-20647560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20647560 |
| http://purl.uniprot.org/uniprot/#_Q18PH8-mappedCitation-20647560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20647560 |
| http://purl.uniprot.org/uniprot/#_P18181-mappedCitation-20647560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20647560 |
| http://purl.uniprot.org/uniprot/#_Q3S4B1-mappedCitation-20647560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20647560 |
| http://purl.uniprot.org/uniprot/#_Q3S4B2-mappedCitation-20647560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20647560 |
| http://purl.uniprot.org/uniprot/#_Q3TAZ6-mappedCitation-20647560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20647560 |
| http://purl.uniprot.org/uniprot/#_Q3TBI0-mappedCitation-20647560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20647560 |