| http://purl.uniprot.org/citations/20657592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20657592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20657592 | http://www.w3.org/2000/01/rdf-schema#comment | "The endocannabinoid 2-arachidonoylglycerol (2-AG) regulates neurotransmission and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 cannabinoid receptors on microglia. Enzymes that hydrolyze 2-AG, such as monoacylglycerol lipase, regulate the accumulation and efficacy of 2-AG at cannabinoid receptors. We found that the recently described serine hydrolase alpha-beta-hydrolase domain 6 (ABHD6) also controls the accumulation and efficacy of 2-AG at cannabinoid receptors. In cells from the BV-2 microglia cell line, ABHD6 knockdown reduced hydrolysis of 2-AG and increased the efficacy with which 2-AG can stimulate CB2-mediated cell migration. ABHD6 was expressed by neurons in primary culture and its inhibition led to activity-dependent accumulation of 2-AG. In adult mouse cortex, ABHD6 was located postsynaptically and its selective inhibition allowed the induction of CB1-dependent long-term depression by otherwise subthreshold stimulation. Our results indicate that ABHD6 is a rate-limiting step of 2-AG signaling and is therefore a bona fide member of the endocannabinoid signaling system."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.2601"xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.2601"xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Xu C."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Xu C."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Lin Y.H."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Lin Y.H."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Alexander J.P."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Alexander J.P."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Blankman J.L."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Blankman J.L."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Bodor A.L."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Bodor A.L."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Coy J."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Coy J."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Cravatt B.F."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Cravatt B.F."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Fung S."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Fung S."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Horne E.A."xsd:string |
| http://purl.uniprot.org/citations/20657592 | http://purl.uniprot.org/core/author | "Horne E.A."xsd:string |