| http://purl.uniprot.org/citations/20658517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20658517 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated the possible functional- and physical protein-interactions between two airway Cl(-) channels, SLC26A9 and CFTR. Bronchial CFBE41o-cell lines expressing CFTR(WT) or CFTR(ΔF508) were transduced with SLC26A9. Immunoblots identified a migrating band corresponding to SLC26A9 present in whole-cell lysates as on apical membrane of cells grown on polarized filters. CFTR levels were increased by the presence of SLC26A9 in both CFTR(WT) and CFTR(ΔF508) cell lines. In CFBE41o-cells and CFBE41o-/CFTR(WT) cells transduced with SLC26A9, currents associated to the protein expression were not detected. However, the forskolin (FK)-stimulated currents were enhanced in SLC26A9-transduced cells compared to control cells. Therefore, the presence of SLC26A9 resulted in an increase in CFTR activity (same % of CFTR((inh)-172) or GlyH-101 inhibition in both groups). In CFBE41o-/CFTR(ΔF508) cells transduced with SLC26A9 (at 27°C), a current associated to the protein expression was also lacking. FK-stimulated currents and level of CFTR((inh)-172) inhibition were not different in both groups. The presence of SLC26A9 in Xenopus oocytes expressing CFTR also enhanced the FK-stimulated currents as compared to oocytes expressing CFTR alone. This stimulation was mostly linked to CFTR. An enhancement of FK-stimulated currents was not found in oocytes co-expressing SLC26A9 and CFTR(ΔF508). In conclusion, in both protein expression systems used, SLC26A9 stimulates CFTR activity but not that of CFTR(ΔF508). Our co-immunoprecipitation studies demonstrate a physical interaction between both anion channels. We propose as an alternative hypothesis (not exclusive) to the known SLC26A9-STAS domain/CFTR interaction, that SLC26A9 favors the biogenesis and/or stabilization of CFTR, leading to stimulated currents."xsd:string |
| http://purl.uniprot.org/citations/20658517 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.22328"xsd:string |
| http://purl.uniprot.org/citations/20658517 | http://purl.uniprot.org/core/author | "Borgese F."xsd:string |
| http://purl.uniprot.org/citations/20658517 | http://purl.uniprot.org/core/author | "Loriol C."xsd:string |
| http://purl.uniprot.org/citations/20658517 | http://purl.uniprot.org/core/author | "Boulukos K."xsd:string |
| http://purl.uniprot.org/citations/20658517 | http://purl.uniprot.org/core/author | "Ehrenfeld J."xsd:string |
| http://purl.uniprot.org/citations/20658517 | http://purl.uniprot.org/core/author | "Avella M."xsd:string |
| http://purl.uniprot.org/citations/20658517 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20658517 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/20658517 | http://purl.uniprot.org/core/pages | "212-223"xsd:string |
| http://purl.uniprot.org/citations/20658517 | http://purl.uniprot.org/core/title | "SLC26A9 stimulates CFTR expression and function in human bronchial cell lines."xsd:string |
| http://purl.uniprot.org/citations/20658517 | http://purl.uniprot.org/core/volume | "226"xsd:string |
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