| http://purl.uniprot.org/citations/20659444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20659444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20659444 | http://www.w3.org/2000/01/rdf-schema#comment | "Cullin-RING ubiquitin ligases (CRLs) are critical regulators of multiple developmental and cellular processes in eukaryotes. CAND1 is a biochemical inhibitor of CRLs, yet has been shown to promote CRL activity in plant and mammalian cells. Here we analyze CAND1 function in the context of a developing metazoan organism. Caenorhabditis elegans CAND-1 is capable of binding to all of the cullins, and we show that it physically interacts with CUL-2 and CUL-4 in vivo. The covalent attachment of the ubiquitin-like protein Nedd8 is required for cullin activity in animals and plants. In cand-1 mutants, the levels of the neddylated isoforms of CUL-2 and CUL-4 are increased, indicating that CAND-1 is a negative regulator of cullin neddylation. cand-1 mutants are hypersensitive to the partial loss of cullin activity, suggesting that CAND-1 facilitates CRL functions. cand-1 mutants exhibit impenetrant phenotypes, including developmental arrest, morphological defects of the vulva and tail, and reduced fecundity. cand-1 mutants share with cul-1 and lin-23 mutants the phenotypes of supernumerary seam cell divisions, defective alae formation, and the accumulation of the SCF(LIN-23) target the glutamate receptor GLR-1. The observation that cand-1 mutants have phenotypes associated with the loss of the SCF(LIN-23) complex, but lack phenotypes associated with other specific CRL complexes, suggests that CAND-1 is differentially required for the activity of distinct CRL complexes."xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2010.07.020"xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2010.07.020"xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/author | "Feng H."xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/author | "Feng H."xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/author | "Kipreos E.T."xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/author | "Kipreos E.T."xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/author | "Min K."xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/author | "Min K."xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/author | "Wallenfang M.R."xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/author | "Wallenfang M.R."xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/author | "Bosu D.R."xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/author | "Bosu D.R."xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/pages | "113-126"xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/pages | "113-126"xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/title | "C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues."xsd:string |
| http://purl.uniprot.org/citations/20659444 | http://purl.uniprot.org/core/title | "C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues."xsd:string |