| http://purl.uniprot.org/citations/20661272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20661272 | http://www.w3.org/2000/01/rdf-schema#comment | "Smokers (≥10 cigarettes per day, N=331) of European ancestry taking part in a double-blind placebo-controlled randomized trial of 12 weeks of treatment with bupropion along with counseling for smoking cessation were genotyped for a variable number of tandem repeats polymorphism in exon III of the dopamine D4 receptor gene. Generalized estimating equations predicting point-prevalence abstinence at end of treatment and 2, 6 and 12 months after the end of treatment indicated that bupropion (vs placebo) predicted increased odds of abstinence. The main effect of Genotype was not significant. A Genotype × Treatment interaction (P=0.005) showed that bupropion predicted increased odds of abstinence in long-allele carriers (odds ratios (OR)=1.31, P<0.0001), whereas bupropion was not associated with abstinence among short-allele homozygotes (OR=1.06, P=0.23). The Genotype × Treatment interaction remained when controlling for demographic and clinical covariates (P=0.01) and in analyses predicting continuous abstinence (P's≤0.054). Bupropion may be more efficacious for smokers who carry the long allele, which is relevant to personalized pharmacogenetic treatment approaches."xsd:string |
| http://purl.uniprot.org/citations/20661272 | http://purl.org/dc/terms/identifier | "doi:10.1038/tpj.2010.64"xsd:string |
| http://purl.uniprot.org/citations/20661272 | http://purl.uniprot.org/core/author | "Brown R.A."xsd:string |
| http://purl.uniprot.org/citations/20661272 | http://purl.uniprot.org/core/author | "Uhl G.R."xsd:string |
| http://purl.uniprot.org/citations/20661272 | http://purl.uniprot.org/core/author | "Munafo M."xsd:string |
| http://purl.uniprot.org/citations/20661272 | http://purl.uniprot.org/core/author | "Strong D."xsd:string |
| http://purl.uniprot.org/citations/20661272 | http://purl.uniprot.org/core/author | "David S.P."xsd:string |
| http://purl.uniprot.org/citations/20661272 | http://purl.uniprot.org/core/author | "Niaura R."xsd:string |
| http://purl.uniprot.org/citations/20661272 | http://purl.uniprot.org/core/author | "McGeary J.E."xsd:string |
| http://purl.uniprot.org/citations/20661272 | http://purl.uniprot.org/core/author | "Lloyd-Richardson E.E."xsd:string |
| http://purl.uniprot.org/citations/20661272 | http://purl.uniprot.org/core/author | "Brightman M."xsd:string |
| http://purl.uniprot.org/citations/20661272 | http://purl.uniprot.org/core/author | "Leventhal A.M."xsd:string |
| http://purl.uniprot.org/citations/20661272 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/20661272 | http://purl.uniprot.org/core/name | "Pharmacogenomics J"xsd:string |
| http://purl.uniprot.org/citations/20661272 | http://purl.uniprot.org/core/pages | "86-92"xsd:string |
| http://purl.uniprot.org/citations/20661272 | http://purl.uniprot.org/core/title | "Dopamine D4 receptor gene variation moderates the efficacy of bupropion for smoking cessation."xsd:string |
| http://purl.uniprot.org/citations/20661272 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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| http://purl.uniprot.org/uniprot/#_Q76E76-mappedCitation-20661272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20661272 |