| http://purl.uniprot.org/citations/20663916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20663916 | http://www.w3.org/2000/01/rdf-schema#comment | "Aurora kinases are central regulators of mitotic-spindle assembly, chromosome segregation and cytokinesis. Aurora B is a member of the chromosomal passenger complex (CPC) with crucial functions in regulation of the attachment of kinetochores to microtubules and in cytokinesis. We report here that Aurora B contains a conserved SUMO modification motif within its kinase domain. Aurora B can bind SUMO peptides in vitro when bound to the IN-box domain of its CPC partner INCENP. Mutation of Lys207 to arginine (Aurora B(K207R)) impairs the formation of conjugates of Aurora B and SUMO in vivo. Expression of the SUMO-null form of Aurora B results in abnormal chromosome segregation and cytokinesis failure and it is not able to rescue mitotic defects in Aurora-B-knockout cells. These defects are accompanied by increased levels of the CPC on chromosome arms and defective centromeric function, as detected by decreased phosphorylation of the Aurora-B substrate CENP-A. The Aurora-B(K207R) mutant does not display reduced kinase activity, suggesting that functional defects are probably a consequence of the altered localization, rather than decreased intrinsic kinase activity. These data suggest that SUMOylation of Aurora B modulates its function, possibly by mediating the extraction of CPC complexes from chromosome arms during prometaphase."xsd:string |
| http://purl.uniprot.org/citations/20663916 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.065565"xsd:string |
| http://purl.uniprot.org/citations/20663916 | http://purl.uniprot.org/core/author | "Montoya G."xsd:string |
| http://purl.uniprot.org/citations/20663916 | http://purl.uniprot.org/core/author | "Earnshaw W.C."xsd:string |
| http://purl.uniprot.org/citations/20663916 | http://purl.uniprot.org/core/author | "Malumbres M."xsd:string |
| http://purl.uniprot.org/citations/20663916 | http://purl.uniprot.org/core/author | "Carmena M."xsd:string |
| http://purl.uniprot.org/citations/20663916 | http://purl.uniprot.org/core/author | "Fernandez-Miranda G."xsd:string |
| http://purl.uniprot.org/citations/20663916 | http://purl.uniprot.org/core/author | "Ruchaud S."xsd:string |
| http://purl.uniprot.org/citations/20663916 | http://purl.uniprot.org/core/author | "Perez de Castro I."xsd:string |
| http://purl.uniprot.org/citations/20663916 | http://purl.uniprot.org/core/author | "Fant X."xsd:string |
| http://purl.uniprot.org/citations/20663916 | http://purl.uniprot.org/core/author | "Aguirre-Portoles C."xsd:string |
| http://purl.uniprot.org/citations/20663916 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20663916 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/20663916 | http://purl.uniprot.org/core/pages | "2823-2833"xsd:string |
| http://purl.uniprot.org/citations/20663916 | http://purl.uniprot.org/core/title | "SUMOylation modulates the function of Aurora-B kinase."xsd:string |
| http://purl.uniprot.org/citations/20663916 | http://purl.uniprot.org/core/volume | "123"xsd:string |
| http://purl.uniprot.org/citations/20663916 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20663916 |
| http://purl.uniprot.org/citations/20663916 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20663916 |
| http://purl.uniprot.org/uniprot/#_P52948-mappedCitation-20663916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20663916 |
| http://purl.uniprot.org/uniprot/#_A8CG34-mappedCitation-20663916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20663916 |
| http://purl.uniprot.org/uniprot/#_P35658-mappedCitation-20663916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20663916 |
| http://purl.uniprot.org/uniprot/#_P37198-mappedCitation-20663916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20663916 |
| http://purl.uniprot.org/uniprot/#_P57740-mappedCitation-20663916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20663916 |
| http://purl.uniprot.org/uniprot/#_Q53HL2-mappedCitation-20663916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20663916 |