| http://purl.uniprot.org/citations/20664056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20664056 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclic adenosine monophosphate (cAMP)-dependent signaling modulates platelet function at sites of vascular injury. Here we show that thrombospondin-1 (TSP-1) prevents cAMP/protein kinase A (PKA) signaling through a CD36-dependent mechanism. Prostaglandin E₁ (PGE₁) induced a robust inhibition of both platelet aggregation and platelet arrest under physiologic conditions of flow. Exogenous TSP-1 reduced significantly PGE₁-mediated inhibition of both platelet aggregation and platelet arrest. TSP-1 prevented PGE₁-stimulated cAMP accrual and phosphorylation of PKA substrates, through a mechanism requiring phosphodiesterase3A. TSP-1 also inhibited VASP phosphorylation stimulated by the nonhydrolyzable cAMP analog, 8-bromo-cAMP, indicating that it may regulate cAMP-mediated activation of PKA. The inhibitory effect of TSP-1 on cAMP signaling could be reproduced with a peptide possessing a CD36 binding sequence of TSP-1, while the effects of TSP-1 were prevented by a CD36 blocking antibody. TSP-1 and the CD36 binding peptide induced phosphorylation of Src kinases, p38 and JNK. Moreover, inhibition of Src kinases blocked TSP-1-mediated regulation of cAMP concentrations and the phosphorylation of VASP, indicating that TSP-1 modulated the cAMP/PKA signaling events through a tyrosine kinase-dependent pathway downstream of CD36. These data reveal a new role for TSP-1 in promoting platelet aggregation through modulation of the cAMP-PKA signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/20664056 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-01-265561"xsd:string |
| http://purl.uniprot.org/citations/20664056 | http://purl.uniprot.org/core/author | "Roberts W."xsd:string |
| http://purl.uniprot.org/citations/20664056 | http://purl.uniprot.org/core/author | "Naseem K.M."xsd:string |
| http://purl.uniprot.org/citations/20664056 | http://purl.uniprot.org/core/author | "Aburima A."xsd:string |
| http://purl.uniprot.org/citations/20664056 | http://purl.uniprot.org/core/author | "Magwenzi S."xsd:string |
| http://purl.uniprot.org/citations/20664056 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20664056 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/20664056 | http://purl.uniprot.org/core/pages | "4297-4306"xsd:string |
| http://purl.uniprot.org/citations/20664056 | http://purl.uniprot.org/core/title | "Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade."xsd:string |
| http://purl.uniprot.org/citations/20664056 | http://purl.uniprot.org/core/volume | "116"xsd:string |
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