Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/20665215http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20665215http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

The role of pharmacogenetics in chemotherapy response in colon carcinoma is controversial. We studied the value of known SNPs in genes involved in 5-FU metabolism as biomarkers of chemotherapy response in patients with stage III colon carcinoma.

Methods

DNA was isolated from normal colonic tissue of 60 patients with stage III colon carcinoma treated adjuvantly with 5-FU combined with leucovorin. The tested SNPs were validated SNPs on the OPRT, TYMS and DPYD genes and a synonymous SNP on the TYMP gene. Real-time PCR, sequencing and RFLP were used for genotyping.

Results

None of the studied genotypes was associated with any of the tumor or patient characteristics. Moreover, none of the genotypes studied had effect on patient survival.

Conclusion

In conclusion, the tested SNPs are not biomarkers of chemotherapy response in our stage III colon cancer patients group."xsd:string
http://purl.uniprot.org/citations/20665215http://purl.org/dc/terms/identifier"doi:10.1007/s00280-010-1403-0"xsd:string
http://purl.uniprot.org/citations/20665215http://purl.uniprot.org/core/author"van Lijnschoten G."xsd:string
http://purl.uniprot.org/citations/20665215http://purl.uniprot.org/core/author"van den Brule A.J."xsd:string
http://purl.uniprot.org/citations/20665215http://purl.uniprot.org/core/author"Farina-Sarasqueta A."xsd:string
http://purl.uniprot.org/citations/20665215http://purl.uniprot.org/core/author"Rutten H.J."xsd:string
http://purl.uniprot.org/citations/20665215http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20665215http://purl.uniprot.org/core/name"Cancer Chemother Pharmacol"xsd:string
http://purl.uniprot.org/citations/20665215http://purl.uniprot.org/core/pages"1167-1171"xsd:string
http://purl.uniprot.org/citations/20665215http://purl.uniprot.org/core/title"Value of gene polymorphisms as markers of 5-FU therapy response in stage III colon carcinoma: a pilot study."xsd:string
http://purl.uniprot.org/citations/20665215http://purl.uniprot.org/core/volume"66"xsd:string
http://purl.uniprot.org/citations/20665215http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20665215
http://purl.uniprot.org/citations/20665215http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20665215
http://purl.uniprot.org/uniprot/#_F2Z303-mappedCitation-20665215http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20665215
http://purl.uniprot.org/uniprot/#_P11172-mappedCitation-20665215http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20665215
http://purl.uniprot.org/uniprot/#_A8K9A5-mappedCitation-20665215http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20665215
http://purl.uniprot.org/uniprot/#_B4DML1-mappedCitation-20665215http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20665215
http://purl.uniprot.org/uniprot/#_A8K5J1-mappedCitation-20665215http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20665215
http://purl.uniprot.org/uniprot/#_B5LY64-mappedCitation-20665215http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20665215
http://purl.uniprot.org/uniprot/#_B5LY67-mappedCitation-20665215http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20665215
http://purl.uniprot.org/uniprot/#_B5LY69-mappedCitation-20665215http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20665215
http://purl.uniprot.org/uniprot/#_B5LY70-mappedCitation-20665215http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20665215
http://purl.uniprot.org/uniprot/#_B5LY71-mappedCitation-20665215http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20665215
http://purl.uniprot.org/uniprot/#_Q12882-mappedCitation-20665215http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20665215
▶