| http://purl.uniprot.org/citations/20665709 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20665709 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20665709 | http://www.w3.org/2000/01/rdf-schema#comment | "In chicken, ovocleidin 116 (OC-116) is found in the eggshell matrix and its encoding gene, OC-116, is expressed in uterine cells. In mammals, its orthologue MEPE encodes the matrix extracellular phosphoglycoprotein (MEPE), which has been shown to be involved in bone mineralization. Using RT-PCR and in situ hybridization on sections, we have checked whether OC-116 was also expressed in osteoblasts and osteocytes during bone development and mineralization in chicken embryos. We monitored OC-116 expression in the tibia and mandible of a growth series of chicken embryos from E3 to E19. Transcripts were identified in the osteoblasts as early as E5 in the tibia and E7 in the mandible, before matrix mineralization, then from these stages onwards in both the osteoblasts lining the mineralized bone matrix and the osteocytes. Therefore, early in chicken ontogeny and as soon as osteogenesis begins, OC-116 is involved. Its function, which remains still unknown, is maintained during further bone growth and mineralization, and later in adult, in which it is recruited for eggshell formation. We hypothesize that the ancestral OC-116/MEPE in a stem amniote was involved in these two functions and that the loss of eggshell in the mammalian lineage has probably favored the recruitment of some MEPE domains toward new functions in osteogenesis and mineralization, and in phosphatemia regulation."xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.org/dc/terms/identifier | "doi:10.1002/jez.b.21366"xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.org/dc/terms/identifier | "doi:10.1002/jez.b.21366"xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/author | "Bardet C."xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/author | "Bardet C."xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/author | "Vincent C."xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/author | "Vincent C."xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/author | "Jaffredo T."xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/author | "Jaffredo T."xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/author | "Sire J.Y."xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/author | "Sire J.Y."xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/author | "Lajarille M.C."xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/author | "Lajarille M.C."xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/name | "J. Exp. Zool. B Mol. Dev. Evol."xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/name | "J. Exp. Zool. B Mol. Dev. Evol."xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/pages | "653-662"xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/pages | "653-662"xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/title | "OC-116, the chicken ortholog of mammalian MEPE found in eggshell, is also expressed in bone cells."xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/title | "OC-116, the chicken ortholog of mammalian MEPE found in eggshell, is also expressed in bone cells."xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/volume | "314"xsd:string |
| http://purl.uniprot.org/citations/20665709 | http://purl.uniprot.org/core/volume | "314"xsd:string |