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http://purl.uniprot.org/citations/20666936http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Aim

To assess the expressions of vascular endothelial growth factor (VEGF), fms-like tyrosine kinase-1 (Flt-1), and soluble Flt-1 (sFlt-1) genes in healthy normotensive and pre-eclamptic placentas of Korean women.

Methods

We investigated 12 healthy normotensive pregnant women and 10 pre-eclamptic pregnant women at Eulji University Hospital. The obtained placental tissues were analyzed using reverse transcription polymerase chain reaction and real-time quantitative polymerase chain reaction.

Results

The sFlt-1 messenger ribonucleic acid (mRNA) level was elevated 2.6 times more in pre-eclamptic placentas than in normal control placentas. However, the VEGF mRNA level of pre-eclamptic placentas was decreased. There was no difference in the Flt-1 mRNA level between control and pre-eclamptic placentas.

Conclusions

Our study showed that expressions of genes relating to angiogenesis were altered in Korean pre-eclamptic placentas. These results suggest that the alteration in expressions of sFlt-1 and VEGF genes might be associated with the pathogenesis of pre-eclampsia."xsd:string
http://purl.uniprot.org/citations/20666936http://purl.org/dc/terms/identifier"doi:10.1111/j.1447-0756.2010.01208.x"xsd:string
http://purl.uniprot.org/citations/20666936http://purl.uniprot.org/core/author"Lee S.K."xsd:string
http://purl.uniprot.org/citations/20666936http://purl.uniprot.org/core/author"Park M.H."xsd:string
http://purl.uniprot.org/citations/20666936http://purl.uniprot.org/core/author"Park J.S."xsd:string
http://purl.uniprot.org/citations/20666936http://purl.uniprot.org/core/author"Yang Y.S."xsd:string
http://purl.uniprot.org/citations/20666936http://purl.uniprot.org/core/author"Baik H.W."xsd:string
http://purl.uniprot.org/citations/20666936http://purl.uniprot.org/core/author"Song Y.R."xsd:string
http://purl.uniprot.org/citations/20666936http://purl.uniprot.org/core/author"Hwang I.T."xsd:string
http://purl.uniprot.org/citations/20666936http://purl.uniprot.org/core/author"Park J.S.'"xsd:string
http://purl.uniprot.org/citations/20666936http://purl.uniprot.org/core/author"Oh K.Y."xsd:string
http://purl.uniprot.org/citations/20666936http://purl.uniprot.org/core/author"Na W.S."xsd:string
http://purl.uniprot.org/citations/20666936http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20666936http://purl.uniprot.org/core/name"J Obstet Gynaecol Res"xsd:string
http://purl.uniprot.org/citations/20666936http://purl.uniprot.org/core/pages"726-732"xsd:string
http://purl.uniprot.org/citations/20666936http://purl.uniprot.org/core/title"Vascular endothelial growth factor, fms-like tyrosine kinase-1 (Flt-1) and soluble Flt-1 gene expressions in Korean pre-eclamptic placentas."xsd:string
http://purl.uniprot.org/citations/20666936http://purl.uniprot.org/core/volume"36"xsd:string
http://purl.uniprot.org/citations/20666936http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20666936
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