| http://purl.uniprot.org/citations/20668019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20668019 | http://www.w3.org/2000/01/rdf-schema#comment | "Emerging preclinical data suggests that tea possess anticarcinogenic and antimutagenic properties. We therefore hypothesize that white tea extract (WTE) is capable of favorably modulating apoptosis, a mechanism associated with lung tumorigenesis. We examined the effects of physiologically relevant doses of WTE on the induction of apoptosis in non-small cell lung cancer cell lines A549 (adenocarcinoma) and H520 (squamous cell carcinoma) cells. We further characterized the molecular mechanisms responsible for WTE-induced apoptosis, including the induction of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and the 15-lipoxygenase (15-LOX) signaling pathways. We found that WTE was effective in inducing apoptosis in both A549 and H520 cells, and inhibition of PPAR-gamma with GW9662 partially reversed WTE-induced apoptosis. We further show that WTE increased PPAR-gamma activation and mRNA expression, concomitantly increased 15(S)-hydroxy-eicosatetraenoic acid release, and upregulated 15-LOX-1 and 15-LOX-2 mRNA expression by A549 cells. Inhibition of 15-LOX with nordihydroguaiaretic acid (NGDA), as well as caffeic acid, abrogated WTE-induced PPAR-gamma activation and upregulation of PPAR-gamma mRNA expression in A549 cells. WTE also induced cyclin-dependent kinase inhibitor 1A mRNA expression and activated caspase-3. Inhibition of caspase-3 abrogated WTE-induced apoptosis. Our findings indicate that WTE is capable of inducing apoptosis in non-small cell lung cancer cell lines. The induction of apoptosis seems to be mediated, in part, through the upregulation of the PPAR-gamma and 15-LOX signaling pathways, with enhanced activation of caspase-3. Our findings support the future investigation of WTE as an antineoplastic and chemopreventive agent for lung cancer."xsd:string |
| http://purl.uniprot.org/citations/20668019 | http://purl.org/dc/terms/identifier | "doi:10.1158/1940-6207.capr-09-0264"xsd:string |
| http://purl.uniprot.org/citations/20668019 | http://purl.uniprot.org/core/author | "Zhang Z.F."xsd:string |
| http://purl.uniprot.org/citations/20668019 | http://purl.uniprot.org/core/author | "Jin Y.S."xsd:string |
| http://purl.uniprot.org/citations/20668019 | http://purl.uniprot.org/core/author | "Lu Q.Y."xsd:string |
| http://purl.uniprot.org/citations/20668019 | http://purl.uniprot.org/core/author | "Mao J.T."xsd:string |
| http://purl.uniprot.org/citations/20668019 | http://purl.uniprot.org/core/author | "Go V.L."xsd:string |
| http://purl.uniprot.org/citations/20668019 | http://purl.uniprot.org/core/author | "Serio K.J."xsd:string |
| http://purl.uniprot.org/citations/20668019 | http://purl.uniprot.org/core/author | "Rao J.Y."xsd:string |
| http://purl.uniprot.org/citations/20668019 | http://purl.uniprot.org/core/author | "Tsu I.H."xsd:string |
| http://purl.uniprot.org/citations/20668019 | http://purl.uniprot.org/core/author | "Nie W.X."xsd:string |
| http://purl.uniprot.org/citations/20668019 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20668019 | http://purl.uniprot.org/core/name | "Cancer Prev Res (Phila)"xsd:string |
| http://purl.uniprot.org/citations/20668019 | http://purl.uniprot.org/core/pages | "1132-1140"xsd:string |
| http://purl.uniprot.org/citations/20668019 | http://purl.uniprot.org/core/title | "White tea extract induces apoptosis in non-small cell lung cancer cells: the role of peroxisome proliferator-activated receptor-{gamma} and 15-lipoxygenases."xsd:string |
| http://purl.uniprot.org/citations/20668019 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/20668019 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20668019 |
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| http://purl.uniprot.org/uniprot/#_B7Z445-mappedCitation-20668019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20668019 |