| http://purl.uniprot.org/citations/20668334 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20668334 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20668334 | http://www.w3.org/2000/01/rdf-schema#comment | "SOX5 is a transcription factor with homology to the high mobility group box region of the testis-determining factor, SRY. Both the mouse and human SOX5 genes encode a 48-kDa SOX5 protein (S-SOX5) that is only present in tissues containing cells with motile cilia/flagella. The mammalian sperm-associated antigen 6 gene (SPAG6) encodes an axoneme central apparatus protein. Because human and mouse SPAG6 gene promoters contain multiple potential binding sites for SOX5, SPAG6 gene regulation by S-SOX5 was investigated in BEAS-2B cells, a line derived from human bronchial cells. Like FOXJ1, a transcription factor known to be essential for motile ciliogenesis, S-SOX5 stimulated mouse and human SPAG6 promoter function in BEAS-2B cells, but the effect was abrogated when the SOX5 binding sites were mutated or deleted. S-SOX5 and FOXJ1 functioned cooperatively in stimulating SPAG6 promoter activity. The SPAG6 message was up-regulated when S-SOX5 was overexpressed in BEAS-2B cells, and silencing of S-SOX5 by RNA interference down-regulated SPAG6 transcripts. Chromatin immunoprecipitation and EMSA experiments demonstrated that S-SOX5 associates with the SPAG6 promoter directly. The present study demonstrates that SPAG6 is a S-SOX5 target gene, indicating a key role for S-SOX5 in the formation and function of motile cilia."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.M110.121590"xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.121590"xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/author | "Song J."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/author | "Song J."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/author | "Shen X."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/author | "Shen X."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/author | "Brody S.L."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/author | "Brody S.L."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/author | "Strauss J.F."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/author | "Gude D.R."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/author | "Gude D.R."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/author | "Strauss J.F.III."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/author | "Kiselak E.A."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/author | "Kiselak E.A."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/20668334 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |