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http://purl.uniprot.org/citations/20673868http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20673868http://www.w3.org/2000/01/rdf-schema#comment"

Objective

We sought to determine whether maternal/fetal single-nucleotide polymorphisms (SNPs) in candidate genes are associated with preterm prelabor rupture of membranes (pPROM).

Study design

A case-control study was conducted in patients with pPROM (225 mothers and 155 fetuses) and 599 mothers and 628 fetuses with a normal pregnancy; 190 candidate genes and 775 SNPs were studied. Single locus/haplotype association analyses were performed; false discovery rate was used to correct for multiple testing (q* = 0.15).

Results

First, a SNP in tissue inhibitor of metalloproteinase 2 in mothers was significantly associated with pPROM (odds ratio, 2.12; 95% confidence interval, 1.47-3.07; P = .000068), and this association remained significant after correction for multiple comparisons. Second, haplotypes for Alpha 3 type IV collagen isoform precursor in the mother were associated with pPROM (global P = .003). Third, multilocus analysis identified a 3-locus model, which included maternal SNPs in collagen type I alpha 2, defensin alpha 5 gene, and endothelin 1.

Conclusion

DNA variants in a maternal gene involved in extracellular matrix metabolism doubled the risk of pPROM."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.org/dc/terms/identifier"doi:10.1016/j.ajog.2010.05.026"xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Lee M.S."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Kim C.J."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Williams S.M."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Vovis G.F."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Romero R."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Gomez R."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Erez O."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Bartlett J."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Hassan S.S."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Tromp G."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Velez Edwards D.R."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Salisbury B.A."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Kusanovic J.P."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Menon R."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Behnke E."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Pearce B.D."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Chaiworapongsa T."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Mazaki-Tovi S."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Anant M.K."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Friel L.A."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Vaisbuch E."xsd:string
http://purl.uniprot.org/citations/20673868http://purl.uniprot.org/core/author"Oyarzun E."xsd:string
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