| http://purl.uniprot.org/citations/20676093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20676093 | http://www.w3.org/2000/01/rdf-schema#comment | "BAFF and APRIL are innate immune mediators that trigger immunoglobulin G (IgG) and IgA class-switch recombination (CSR) in B cells by engaging the receptor TACI. The mechanism that underlies CSR signaling by TACI remains unknown. Here we found that the cytoplasmic domain of TACI encompasses a conserved motif that bound MyD88, an adaptor that activates transcription factor NF-kappaB signaling pathways via a Toll-interleukin 1 (IL-1) receptor (TIR) domain. TACI lacks a TIR domain, yet triggered CSR via the DNA-editing enzyme AID by activating NF-kappaB through a Toll-like receptor (TLR)-like MyD88-IRAK1-IRAK4-TRAF6-TAK1 pathway. TACI-induced CSR was impaired in mice and humans lacking MyD88 or the kinase IRAK4, which indicates that MyD88 controls a B cell-intrinsic, TIR-independent, TACI-dependent pathway for immunoglobulin diversification."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1914"xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "He B."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Xiong H."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Chen K."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Casanova J.L."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Grimbacher B."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Davies G."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Meffre E."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Plebani A."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Santamaria R."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Krause J."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Picard C."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Marodi L."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Puel A."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Cunningham-Rundles C."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Reichenbach J."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Doffinger R."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Vasconcelos J."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Issekutz A."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Cerutti A."xsd:string |
| http://purl.uniprot.org/citations/20676093 | http://purl.uniprot.org/core/author | "Chiu A."xsd:string |