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http://purl.uniprot.org/citations/20678810http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20678810http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The risk of multiple sclerosis (MS) is influenced by HLA-DRB1, while protective effects have been proposed for HLA-A*02 and HLA-C*05. Our aim was to further understand the role of HLA class I in MS through a comprehensive investigation.

Methods

1529 MS patients and 1814 controls from Sweden and Norway were genotyped for HLA-DRB1, HLA-A, and HLA-C. Simultaneous analysis of all alleles while adjusting for confounding was achieved using logistic regression.

Results

We observed independent effects of all three genes. We confirm the HLA-A*02 (OR=0.73, p=9.2 x 10(-4)) association and report a novel effect of HLA-C*08 (OR=1.85, p=0.0093).

Conclusions

The HLA class I region contains two factors modulating MS risk, characterized by independent associations with HLA-A and HLA-C."xsd:string
http://purl.uniprot.org/citations/20678810http://purl.org/dc/terms/identifier"doi:10.1016/j.jneuroim.2010.07.006"xsd:string
http://purl.uniprot.org/citations/20678810http://purl.uniprot.org/core/author"Link J."xsd:string
http://purl.uniprot.org/citations/20678810http://purl.uniprot.org/core/author"Hillert J."xsd:string
http://purl.uniprot.org/citations/20678810http://purl.uniprot.org/core/author"Kockum I."xsd:string
http://purl.uniprot.org/citations/20678810http://purl.uniprot.org/core/author"Celius E.G."xsd:string
http://purl.uniprot.org/citations/20678810http://purl.uniprot.org/core/author"Harbo H.F."xsd:string
http://purl.uniprot.org/citations/20678810http://purl.uniprot.org/core/author"Lorentzen A.R."xsd:string
http://purl.uniprot.org/citations/20678810http://purl.uniprot.org/core/author"Lie B.A."xsd:string
http://purl.uniprot.org/citations/20678810http://purl.uniprot.org/core/author"Duvefelt K."xsd:string
http://purl.uniprot.org/citations/20678810http://purl.uniprot.org/core/author"Brynedal B."xsd:string
http://purl.uniprot.org/citations/20678810http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20678810http://purl.uniprot.org/core/name"J Neuroimmunol"xsd:string
http://purl.uniprot.org/citations/20678810http://purl.uniprot.org/core/pages"172-176"xsd:string
http://purl.uniprot.org/citations/20678810http://purl.uniprot.org/core/title"Two HLA class I genes independently associated with multiple sclerosis."xsd:string
http://purl.uniprot.org/citations/20678810http://purl.uniprot.org/core/volume"226"xsd:string
http://purl.uniprot.org/citations/20678810http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20678810
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http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-20678810http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20678810
http://purl.uniprot.org/uniprot/#_A0A0A7C549-mappedCitation-20678810http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20678810
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