| http://purl.uniprot.org/citations/20678979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20678979 | http://www.w3.org/2000/01/rdf-schema#comment | "Developmental timing in the nematode Caenorhabditis elegans is controlled by heterochronic genes, mutations in which cause changes in the relative timing of developmental events. One of the heterochronic genes, let-7, encodes a microRNA that is highly evolutionarily conserved, suggesting that similar genetic pathways control developmental timing across phyla. Here we report that the nuclear receptor nhr-25, which belongs to the evolutionarily conserved fushi tarazu-factor 1/nuclear receptor NR5A subfamily, interacts with heterochronic genes that regulate the larva-to-adult transition in C. elegans. We identified nhr-25 as a regulator of apl-1, a homolog of the Alzheimer's amyloid precursor protein-like gene that is downstream of let-7 family microRNAs. NHR-25 controls not only apl-1 expression but also regulates developmental progression in the larva-to-adult transition. NHR-25 negatively regulates the expression of the adult-specific collagen gene col-19 in lateral epidermal seam cells. In contrast, NHR-25 positively regulates the larva-to-adult transition for other timed events in seam cells, such as cell fusion, cell division and alae formation. The genetic relationships between nhr-25 and other heterochronic genes are strikingly varied among several adult developmental events. We propose that nhr-25 has multiple roles in both promoting and inhibiting the C. elegans heterochronic gene pathway controlling adult differentiation programs."xsd:string |
| http://purl.uniprot.org/citations/20678979 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2010.05.508"xsd:string |
| http://purl.uniprot.org/citations/20678979 | http://purl.uniprot.org/core/author | "Niwa R."xsd:string |
| http://purl.uniprot.org/citations/20678979 | http://purl.uniprot.org/core/author | "Slack F.J."xsd:string |
| http://purl.uniprot.org/citations/20678979 | http://purl.uniprot.org/core/author | "Hasegawa H."xsd:string |
| http://purl.uniprot.org/citations/20678979 | http://purl.uniprot.org/core/author | "Hada K."xsd:string |
| http://purl.uniprot.org/citations/20678979 | http://purl.uniprot.org/core/author | "Kanaho Y."xsd:string |
| http://purl.uniprot.org/citations/20678979 | http://purl.uniprot.org/core/author | "Asahina M."xsd:string |
| http://purl.uniprot.org/citations/20678979 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20678979 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/20678979 | http://purl.uniprot.org/core/pages | "1100-1109"xsd:string |
| http://purl.uniprot.org/citations/20678979 | http://purl.uniprot.org/core/title | "The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition."xsd:string |
| http://purl.uniprot.org/citations/20678979 | http://purl.uniprot.org/core/volume | "344"xsd:string |
| http://purl.uniprot.org/citations/20678979 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20678979 |
| http://purl.uniprot.org/citations/20678979 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20678979 |
| http://purl.uniprot.org/uniprot/#_A0A131MAT8-mappedCitation-20678979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20678979 |
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| http://purl.uniprot.org/uniprot/#_A0A131MCB3-mappedCitation-20678979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20678979 |
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| http://purl.uniprot.org/uniprot/#_A0A6V7QZ48-mappedCitation-20678979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20678979 |
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| http://purl.uniprot.org/uniprot/#_P41828-mappedCitation-20678979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20678979 |