| http://purl.uniprot.org/citations/20679435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20679435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20679435 | http://www.w3.org/2000/01/rdf-schema#comment | "EphA2, a member of the Eph receptor family, is frequently overexpressed in a variety of human cancers, including breast cancers, and promotes cancer cell motility and invasion independently of its ligand ephrin stimulation. In this study, we identify Ephexin4 as a guanine nucleotide exchange factor (GEF) for RhoG that interacts with EphA2 in breast cancer cells, and knockdown and rescue experiments show that Ephexin4 acts downstream of EphA2 to promote ligand-independent breast cancer cell migration and invasion toward epidermal growth factor through activation of RhoG. The activation of RhoG recruits its effector ELMO2 and a Rac GEF Dock4 to form a complex with EphA2 at the tips of cortactin-rich protrusions in migrating breast cancer cells. In addition, the Dock4-mediated Rac activation is required for breast cancer cell migration. Our findings reveal a novel link between EphA2 and Rac activation that contributes to the cell motility and invasiveness of breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201005141"xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201005141"xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/author | "Fujimoto S."xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/author | "Fujimoto S."xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/author | "Harada K."xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/author | "Harada K."xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/author | "Negishi M."xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/author | "Negishi M."xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/author | "Katoh H."xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/author | "Katoh H."xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/author | "Ueda S."xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/author | "Ueda S."xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/author | "Takeuchi S."xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/author | "Takeuchi S."xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/author | "Hiramoto-Yamaki N."xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/author | "Hiramoto-Yamaki N."xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/pages | "461-477"xsd:string |
| http://purl.uniprot.org/citations/20679435 | http://purl.uniprot.org/core/pages | "461-477"xsd:string |