| http://purl.uniprot.org/citations/20680465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20680465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20680465 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor AP-1 plays an important role in cellular proliferation, transformation and death. In this study, we report a novel human gene, AC3-33 (GenBank name: c3orf33, FLJ31139), which encodes a secretory protein that can inhibit Elk1 transcriptional activity via ERK1/2 pathway. The AC3-33 mRNA encodes a protein of 251 amino acids, which is a classical secretory protein. Functional investigation reveals that overexpression of AC3-33 significantly inhibit AP-1 activity and DNA-binding ability. Further investigation indicated that overexpression of AC3-33 significantly inhibit transcriptional activity of Elk1 and c-jun, but not c-fos. As for the upstream of signaling pathway of Elk-1, our study demonstrated that overexpression of AC3-33 significantly down-regulates phosphorylation of ERK1/2, but not JNK/SAPK or p38 MAPK. These results clearly indicate that AC3-33 is a novel member of the secretory family and inhibits Elk1 transcriptional activity via ERK1/2 MAPK."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11033-010-0240-x"xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11033-010-0240-x"xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Liu P."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Liu P."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Yang W."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Gao P."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Gao P."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Shi T."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Shi T."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Hao D."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/author | "Hao D."xsd:string |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20680465 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |