| http://purl.uniprot.org/citations/20686879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20686879 | http://www.w3.org/2000/01/rdf-schema#comment | "C-reactive protein (CRP) is one of the acute-phase proteins produced predominantly by hepatocytes in response to inflammation, and it has been widely reported that CRP genetic polymorphism is a risk factor for cardiovascular disease and ischemic stroke. In addition, we previously showed that the CRP 1846T/T genotype is related to lymph node metastasis in patients with esophageal cancer. In the present study, we investigated the correlation between CRP 1846C>T polymorphism and the clinicopathological characteristics of non-small cell lung cancer (NSCLC). The study participants were 146 Japanese patients who underwent curative surgery for NSCLC. DNA was extracted from tumor samples, and CRP1846C>T polymorphism was investigated using the polymerase chain reaction-restriction fragment length polymorphism method. We then correlated genotype with known clinicopathological factors. Five-year overall survival among patients with the CRP 1846T/T genotype was significantly lower than among those with the 1846C/C or C/T genotype (p = 0.002, p = 0.001; log-rank test). Multivariate Cox proportional hazard analysis revealed age, sex, pathological stage III, and 1846T/T (hazard ratio, 1.76; 95% confidence interval, 1.003-3.16; p = 0.049) to be independent factors affecting 5-year overall survival. These findings suggest the CRP 1846T/T genotype is an independent predictor of a poor prognosis in patients with NSCLC."xsd:string |
| http://purl.uniprot.org/citations/20686879 | http://purl.org/dc/terms/identifier | "doi:10.1007/s13277-010-0086-9"xsd:string |
| http://purl.uniprot.org/citations/20686879 | http://purl.uniprot.org/core/author | "Ito M."xsd:string |
| http://purl.uniprot.org/citations/20686879 | http://purl.uniprot.org/core/author | "Ono T."xsd:string |
| http://purl.uniprot.org/citations/20686879 | http://purl.uniprot.org/core/author | "Saito H."xsd:string |
| http://purl.uniprot.org/citations/20686879 | http://purl.uniprot.org/core/author | "Miura M."xsd:string |
| http://purl.uniprot.org/citations/20686879 | http://purl.uniprot.org/core/author | "Imai K."xsd:string |
| http://purl.uniprot.org/citations/20686879 | http://purl.uniprot.org/core/author | "Ogawa J."xsd:string |
| http://purl.uniprot.org/citations/20686879 | http://purl.uniprot.org/core/author | "Motoyama S."xsd:string |
| http://purl.uniprot.org/citations/20686879 | http://purl.uniprot.org/core/author | "Minamiya Y."xsd:string |
| http://purl.uniprot.org/citations/20686879 | http://purl.uniprot.org/core/author | "Hinai Y."xsd:string |
| http://purl.uniprot.org/citations/20686879 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20686879 | http://purl.uniprot.org/core/name | "Tumour Biol"xsd:string |
| http://purl.uniprot.org/citations/20686879 | http://purl.uniprot.org/core/pages | "673-679"xsd:string |
| http://purl.uniprot.org/citations/20686879 | http://purl.uniprot.org/core/title | "The CRP 1846T/T genotype is associated with a poor prognosis in patients with non-small cell lung cancer."xsd:string |
| http://purl.uniprot.org/citations/20686879 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/20686879 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20686879 |
| http://purl.uniprot.org/citations/20686879 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20686879 |
| http://purl.uniprot.org/uniprot/#_C9JRE9-mappedCitation-20686879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20686879 |
| http://purl.uniprot.org/uniprot/#_P02741-mappedCitation-20686879 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20686879 |
| http://purl.uniprot.org/uniprot/C9JRE9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20686879 |
| http://purl.uniprot.org/uniprot/P02741 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20686879 |