| http://purl.uniprot.org/citations/20689042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20689042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20689042 | http://www.w3.org/2000/01/rdf-schema#comment | "The ternary complex of cadherin, beta-catenin, and alpha-catenin regulates actin-dependent cell-cell adhesion. alpha-Catenin can bind beta-catenin and F-actin, but in mammals alpha-catenin either binds beta-catenin as a monomer or F-actin as a homodimer. It is not known if this conformational regulation of alpha-catenin is evolutionarily conserved. The Caenorhabditis elegans alpha-catenin homolog HMP-1 is essential for actin-dependent epidermal enclosure and embryo elongation. Here we show that HMP-1 is a monomer with a functional C-terminal F-actin binding domain. However, neither full-length HMP-1 nor a ternary complex of HMP-1-HMP-2(beta-catenin)-HMR-1(cadherin) bind F-actin in vitro, suggesting that HMP-1 is auto-inhibited. Truncation of either the F-actin or HMP-2 binding domain of HMP-1 disrupts C. elegans development, indicating that HMP-1 must be able to bind F-actin and HMP-2 to function in vivo. Our study defines evolutionarily conserved properties of alpha-catenin and suggests that multiple mechanisms regulate alpha-catenin binding to F-actin."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1007349107"xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1007349107"xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Choi H.J."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Choi H.J."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Pokutta S."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Pokutta S."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Weis W.I."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Weis W.I."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Nelson W.J."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Nelson W.J."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Hardin J."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Hardin J."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Lynch A.M."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Lynch A.M."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Kwiatkowski A.V."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Kwiatkowski A.V."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Benjamin J.M."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Benjamin J.M."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Maiden S.L."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/author | "Maiden S.L."xsd:string |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20689042 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |