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http://purl.uniprot.org/citations/20691532http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20691532http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The aim of our study was to investigate the association of HLA-DRB1 and -DQB1 alleles with multiple sclerosis (MS) in a Tunisian population and their effect on age at onset and disease severity.

Methods

58 MS patients and 105 healthy controls were genotyped for HLA class II alleles by PCR-SSP technique.

Results

An association of MS with HLA-DRB1*15 was found (14.7% vs 3.8%, OR (95% CI)=4.34 (1.69-11.39), p(c)=2.5×10(-3)) after Bonferroni's correction. Moreover, the DRB1*15-DQB1*06 (13.8% vs 2.8%, OR (95% CI)=5.44 (1.92-17.41), p(c)=1.1×10(-3)) and DRB1*04-DQB1*04 (8.6% vs 1.9%, OR (95% CI)=4.86 (1.36-21.62), p(c)=0.028) haplotypes were found to confer a susceptibility to multiple sclerosis.

Conclusion

To our knowledge, this is the first study performed to analyze the association of HLA-DRB1/DQB1 alleles on MS susceptibility in Tunisia. The modern Tunisian gene pool shows some degree of heterogeneity and reflects a significant gene flow from Mediterranean regions."xsd:string
http://purl.uniprot.org/citations/20691532http://purl.org/dc/terms/identifier"doi:10.1016/j.clineuro.2010.07.004"xsd:string
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/author"Raies A."xsd:string
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/author"Messadi A."xsd:string
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/author"Ouerhani S."xsd:string
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/author"Layouni S."xsd:string
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/author"Gritli N."xsd:string
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/author"Mrissa R."xsd:string
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/author"Nciri B."xsd:string
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/author"Yedeas M."xsd:string
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/author"Zaweli J."xsd:string
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/author"Bouaicha G."xsd:string
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/author"Kouki W."xsd:string
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/author"Louatti I."xsd:string
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/author"Najiba F.M."xsd:string
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/name"Clin Neurol Neurosurg"xsd:string
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/pages"849-852"xsd:string
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/title"HLA class II alleles and multiple sclerosis in Tunisian patients."xsd:string
http://purl.uniprot.org/citations/20691532http://purl.uniprot.org/core/volume"112"xsd:string
http://purl.uniprot.org/citations/20691532http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20691532
http://purl.uniprot.org/citations/20691532http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20691532
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-20691532http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20691532
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-20691532http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20691532
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