| http://purl.uniprot.org/citations/20691628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20691628 | http://www.w3.org/2000/01/rdf-schema#comment | "Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance mechanism that in mammals generally occurs upon recognition of a premature termination codon (PTC) during a pioneer round of translation. This round involves newly synthesized mRNA that is bound at its 5' end by the cap-binding protein (CBP) heterodimer CBP80-CBP20. Here we show that precluding the binding of the NMD factor UPF1 to CBP80 inhibits NMD at two steps: the association of SMG1 and UPF1 with the two eukaryotic release factors (eRFs) during SURF complex formation at a PTC, and the subsequent association of SMG1 and UPF1 with an exon-junction complex. We also demonstrate that UPF1 binds PTC-containing mRNA more efficiently than the corresponding PTC-free mRNA in a way that is promoted by the UPF1-CBP80 interaction. A unifying model proposes a choreographed series of protein-protein interactions occurring on an NMD target."xsd:string |
| http://purl.uniprot.org/citations/20691628 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2010.07.004"xsd:string |
| http://purl.uniprot.org/citations/20691628 | http://purl.uniprot.org/core/author | "Hwang J."xsd:string |
| http://purl.uniprot.org/citations/20691628 | http://purl.uniprot.org/core/author | "Tang Y."xsd:string |
| http://purl.uniprot.org/citations/20691628 | http://purl.uniprot.org/core/author | "Sato H."xsd:string |
| http://purl.uniprot.org/citations/20691628 | http://purl.uniprot.org/core/author | "Maquat L.E."xsd:string |
| http://purl.uniprot.org/citations/20691628 | http://purl.uniprot.org/core/author | "Matsuda D."xsd:string |
| http://purl.uniprot.org/citations/20691628 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20691628 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/20691628 | http://purl.uniprot.org/core/pages | "396-409"xsd:string |
| http://purl.uniprot.org/citations/20691628 | http://purl.uniprot.org/core/title | "UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps."xsd:string |
| http://purl.uniprot.org/citations/20691628 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/20691628 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20691628 |
| http://purl.uniprot.org/citations/20691628 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20691628 |
| http://purl.uniprot.org/uniprot/#_A0A024R7L5-mappedCitation-20691628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20691628 |
| http://purl.uniprot.org/uniprot/#_A0A059X4U2-mappedCitation-20691628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20691628 |
| http://purl.uniprot.org/uniprot/#_A0A059XAJ5-mappedCitation-20691628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20691628 |
| http://purl.uniprot.org/uniprot/#_A0A059XAL2-mappedCitation-20691628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20691628 |
| http://purl.uniprot.org/uniprot/#_A0A059XAL6-mappedCitation-20691628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20691628 |
| http://purl.uniprot.org/uniprot/#_A0A059XAM1-mappedCitation-20691628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20691628 |
| http://purl.uniprot.org/uniprot/#_A0A059XBJ1-mappedCitation-20691628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20691628 |
| http://purl.uniprot.org/uniprot/#_A0A059XBJ6-mappedCitation-20691628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20691628 |
| http://purl.uniprot.org/uniprot/#_A0A059XG67-mappedCitation-20691628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20691628 |
| http://purl.uniprot.org/uniprot/#_A0A059XG73-mappedCitation-20691628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20691628 |