| http://purl.uniprot.org/citations/20691903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20691903 | http://www.w3.org/2000/01/rdf-schema#comment | "Opposing roles of Aurora kinases and protein phosphatase 1 (PP1) during mitosis have long been suggested. Here, we demonstrate that Aurora kinases A and B phosphorylate a conserved residue on the kinetochore motor CENP-E. PP1 binds CENP-E via a motif overlapping this phosphorylation site and binding is disrupted by Aurora phosphorylation. Phosphorylation of CENP-E by the Auroras is enriched at spindle poles, disrupting binding of PP1 and reducing CENP-E's affinity for individual microtubules. This phosphorylation is required for CENP-E-mediated towing of initially polar chromosomes toward the cell center. Kinetochores on such chromosomes cannot make subsequent stable attachment to spindle microtubules when dephosphorylation of CENP-E or rebinding of PP1 to CENP-E is blocked. Thus, an Aurora/PP1 phosphorylation switch modulates CENP-E motor activity as an essential feature of chromosome congression from poles and localized PP1 delivery by CENP-E to the outer kinetochore is necessary for stable microtubule capture by those chromosomes."xsd:string |
| http://purl.uniprot.org/citations/20691903 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2010.06.039"xsd:string |
| http://purl.uniprot.org/citations/20691903 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/20691903 | http://purl.uniprot.org/core/author | "Lan W."xsd:string |
| http://purl.uniprot.org/citations/20691903 | http://purl.uniprot.org/core/author | "Cleveland D.W."xsd:string |
| http://purl.uniprot.org/citations/20691903 | http://purl.uniprot.org/core/author | "Holland A.J."xsd:string |
| http://purl.uniprot.org/citations/20691903 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20691903 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/20691903 | http://purl.uniprot.org/core/pages | "444-455"xsd:string |
| http://purl.uniprot.org/citations/20691903 | http://purl.uniprot.org/core/title | "Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E."xsd:string |
| http://purl.uniprot.org/citations/20691903 | http://purl.uniprot.org/core/volume | "142"xsd:string |
| http://purl.uniprot.org/citations/20691903 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20691903 |
| http://purl.uniprot.org/citations/20691903 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20691903 |
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| http://purl.uniprot.org/uniprot/#_O13024-mappedCitation-20691903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20691903 |
| http://purl.uniprot.org/uniprot/#_Q02224-mappedCitation-20691903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20691903 |
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