| http://purl.uniprot.org/citations/20692235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20692235 | http://www.w3.org/2000/01/rdf-schema#comment | "Autotaxin, encoded by the Enpp2 gene, generates lysophosphatidic acid (LPA) extracellularly, eliciting various cellular responses through specific LPA receptors. Previous studies have revealed that Enpp2(-/-) mice die at E9.5 owing to angiogenic defects in the yolk sac. Moreover, Enpp2(-/-) embryos show growth retardation, allantois malformation, no axial turning, and head cavity formation. We have also demonstrated that lysosome biogenesis is impaired in yolk sac visceral endoderm cells of Enpp2(-/-) embryos as a result of the downregulation of the Rho-ROCK (Rho-associated coiled-coil containing protein kinase)-LIM kinase pathway. In this study, we examine what signaling defect(s) is responsible for head cavity formation and yolk sac angiogenic defects. By using a whole embryo culture system, we show that 10 μM Ki16425, an antagonist for the LPA receptors, induces head cavity formation and yolk sac angiogenic defects in wild-type embryos. Moreover, 1 μM Ki16425 induces both phenotypes in Enpp2 heterozygous embryos at significantly higher incidence than in wild-type embryos, suggesting an interaction between autotaxin and LPA receptor signaling. Furthermore, we show that inhibition of the Rho-ROCK pathway induces head cavity formation, whereas multiple pathways are involved in yolk sac angiogenic defects. These results reveal the signal transduction defects that underlie the abnormalities in Enpp2(-/-) embryos."xsd:string |
| http://purl.uniprot.org/citations/20692235 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2010.08.008"xsd:string |
| http://purl.uniprot.org/citations/20692235 | http://purl.uniprot.org/core/author | "Koike S."xsd:string |
| http://purl.uniprot.org/citations/20692235 | http://purl.uniprot.org/core/author | "Keino-Masu K."xsd:string |
| http://purl.uniprot.org/citations/20692235 | http://purl.uniprot.org/core/author | "Masu M."xsd:string |
| http://purl.uniprot.org/citations/20692235 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20692235 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/20692235 | http://purl.uniprot.org/core/pages | "66-71"xsd:string |
| http://purl.uniprot.org/citations/20692235 | http://purl.uniprot.org/core/title | "Deficiency of autotaxin/lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway."xsd:string |
| http://purl.uniprot.org/citations/20692235 | http://purl.uniprot.org/core/volume | "400"xsd:string |
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