| http://purl.uniprot.org/citations/20693425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20693425 | http://www.w3.org/2000/01/rdf-schema#comment | "The signaling and adaptor protein Homer3 plays a role in controlling immune homeostasis and self-reactivity. Homer3 is recruited to the immune synapse (IS) following TCR ligation, although the mechanisms regulating this subcellular localization are unknown. We show that Homer3 specifically associates with a novel ubiquitin-like domain in the IkappaB kinase (IKK) beta subunit of the IKK complex. Homer3 associates with IKKbeta in T cells and colocalizes with the IKK complex at the IS. However, Homer3 is not required for IKK activation, as NF-kappaB signaling is intact in Homer3-deficient T cells. Instead, the IKK complex recruits Homer3 to the IS following TCR engagement, and we present evidence that this association regulates actin dynamics in T cells. These findings identify a novel interaction between two major signaling proteins and reveal an unexpected NF-kappaB-independent function for the IKK complex in regulating the subcellular localization of Homer3."xsd:string |
| http://purl.uniprot.org/citations/20693425 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0903488"xsd:string |
| http://purl.uniprot.org/citations/20693425 | http://purl.uniprot.org/core/author | "Kang S."xsd:string |
| http://purl.uniprot.org/citations/20693425 | http://purl.uniprot.org/core/author | "May M.J."xsd:string |
| http://purl.uniprot.org/citations/20693425 | http://purl.uniprot.org/core/author | "Worley P.F."xsd:string |
| http://purl.uniprot.org/citations/20693425 | http://purl.uniprot.org/core/author | "Orange J.S."xsd:string |
| http://purl.uniprot.org/citations/20693425 | http://purl.uniprot.org/core/author | "Banerjee P.P."xsd:string |
| http://purl.uniprot.org/citations/20693425 | http://purl.uniprot.org/core/author | "McCorkell K.A."xsd:string |
| http://purl.uniprot.org/citations/20693425 | http://purl.uniprot.org/core/author | "Solt L.A."xsd:string |
| http://purl.uniprot.org/citations/20693425 | http://purl.uniprot.org/core/author | "Hanson E.P."xsd:string |
| http://purl.uniprot.org/citations/20693425 | http://purl.uniprot.org/core/author | "Madge L.A."xsd:string |
| http://purl.uniprot.org/citations/20693425 | http://purl.uniprot.org/core/author | "Yatherajam G."xsd:string |
| http://purl.uniprot.org/citations/20693425 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20693425 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20693425 | http://purl.uniprot.org/core/pages | "2665-2669"xsd:string |
| http://purl.uniprot.org/citations/20693425 | http://purl.uniprot.org/core/title | "Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3."xsd:string |
| http://purl.uniprot.org/citations/20693425 | http://purl.uniprot.org/core/volume | "185"xsd:string |
| http://purl.uniprot.org/citations/20693425 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20693425 |
| http://purl.uniprot.org/citations/20693425 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20693425 |
| http://purl.uniprot.org/uniprot/#_Q5U0L9-mappedCitation-20693425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20693425 |
| http://purl.uniprot.org/uniprot/#_Q9NSC5-mappedCitation-20693425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20693425 |
| http://purl.uniprot.org/uniprot/Q9NSC5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20693425 |
| http://purl.uniprot.org/uniprot/Q5U0L9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20693425 |