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http://purl.uniprot.org/citations/20696662http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20696662http://www.w3.org/2000/01/rdf-schema#comment"

Background

rs10993994, a single nucleotide polymorphism (SNP) at the genetic locus encoding beta-microseminoprotein (beta-MSP), is associated with both prostate cancer risk and levels of blood prostate-specific antigen (PSA), a biomarker used in prostate cancer screening. Therefore, we wished to determine the association between SNPs at MSMB, the gene encoding beta-MSP, and the levels of prostate-produced biomarkers beta-MSP, PSA, and human kallikrein 2 (hK2) in blood and semen.

Methods

Blood and semen from 304 healthy young Swedish men (ages 18-21) were assayed for beta-MSP, PSA, and hK2. SNPs around MSMB were genotyped from matched DNA and analyzed for quantitative association with biomarker levels. Empirical P values were multiple test-corrected and the independence of each SNP's effect was determined.

Results

rs10993994 was significantly associated with the blood and semen levels of beta-MSP (both P < 1.0 x 10(-7)) and PSA (P = 0.00014 and P = 0.0019), and semen levels of hK2 (P = 0.00027). Additional copies of the prostate cancer risk allele resulted in lower beta-MSP but higher PSA levels, and singly explained 23% and 5% of the variation seen in semen beta-MSP and PSA, respectively. Additional SNPs at MSMB are associated with beta-MSP and PSA independently of rs10993994.

Conclusions

SNPs at MSMB correlate with physiologic variation in beta-MSP and PSA levels in the blood and semen of healthy young Swedish men. In particular, rs10993994 has a strong effect on beta-MSP levels.

Impact

Our results suggest a mechanism by which rs10993994 might predispose to prostate cancer and raise the possibility that genetic variation might need to be considered in interpreting the levels of these biomarkers."xsd:string
http://purl.uniprot.org/citations/20696662http://purl.org/dc/terms/identifier"doi:10.1158/1055-9965.epi-10-0431"xsd:string
http://purl.uniprot.org/citations/20696662http://purl.uniprot.org/core/author"Xu X."xsd:string
http://purl.uniprot.org/citations/20696662http://purl.uniprot.org/core/author"Klein R.J."xsd:string
http://purl.uniprot.org/citations/20696662http://purl.uniprot.org/core/author"Lilja H."xsd:string
http://purl.uniprot.org/citations/20696662http://purl.uniprot.org/core/author"Valtonen-Andre C."xsd:string
http://purl.uniprot.org/citations/20696662http://purl.uniprot.org/core/author"Hallden C."xsd:string
http://purl.uniprot.org/citations/20696662http://purl.uniprot.org/core/author"Savblom C."xsd:string
http://purl.uniprot.org/citations/20696662http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20696662http://purl.uniprot.org/core/name"Cancer Epidemiol Biomarkers Prev"xsd:string
http://purl.uniprot.org/citations/20696662http://purl.uniprot.org/core/pages"2035-2042"xsd:string
http://purl.uniprot.org/citations/20696662http://purl.uniprot.org/core/title"Polymorphisms at the Microseminoprotein-beta locus associated with physiologic variation in beta-microseminoprotein and prostate-specific antigen levels."xsd:string
http://purl.uniprot.org/citations/20696662http://purl.uniprot.org/core/volume"19"xsd:string
http://purl.uniprot.org/citations/20696662http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20696662
http://purl.uniprot.org/citations/20696662http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20696662
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http://purl.uniprot.org/uniprot/P08118http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20696662
http://purl.uniprot.org/uniprot/B2R597http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20696662