| http://purl.uniprot.org/citations/20699362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20699362 | http://www.w3.org/2000/01/rdf-schema#comment | "The oxysterol-producing enzyme CH25H plays an important role in regulating lipid metabolism, gene expression, and immune activation. In vitro experiments using a panel of TLR agonists to activate BMDCs and macrophages demonstrated that Ch25h expression is induced rapidly, selectively, and robustly by the TLR ligands poly I:C and LPS. The mechanism of TLR3- and TLR4-induced transcription levels of Ch25h relies on the TRIF-mediated production of type I IFNs and requires signaling through the IFNαR and JAK/STAT1 pathway. Treatment of BMDCs and macrophages with IFN-α or IFN-β induces Ch25h in a STAT1-dependent manner. IFN-γ also up-regulated Ch25h expression by signaling through STAT1, suggesting that multiple pathways regulate the production of this enzyme. In addition, we demonstrated that regulation of Ch25h expression in vivo in lung-derived DCs and macrophages is dependent on signaling through the IFNαR and STAT1. The results suggest that the rapid induction of Ch25h and subsequent oxysterol synthesis may represent a component of the regulatory network that modulates the magnitude of innate immune reactions and possibly the nature and intensity of subsequent adaptive responses."xsd:string |
| http://purl.uniprot.org/citations/20699362 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.0610318"xsd:string |
| http://purl.uniprot.org/citations/20699362 | http://purl.uniprot.org/core/author | "Park K."xsd:string |
| http://purl.uniprot.org/citations/20699362 | http://purl.uniprot.org/core/author | "Scott A.L."xsd:string |
| http://purl.uniprot.org/citations/20699362 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20699362 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/20699362 | http://purl.uniprot.org/core/pages | "1081-1087"xsd:string |
| http://purl.uniprot.org/citations/20699362 | http://purl.uniprot.org/core/title | "Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons."xsd:string |
| http://purl.uniprot.org/citations/20699362 | http://purl.uniprot.org/core/volume | "88"xsd:string |
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