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http://purl.uniprot.org/citations/20703861http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20703861http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

The aim of this study was to determine if glucose transporter-1 (Glut1) expression correlates with (18)F-FDG ((18)F-fluoro-2-deoxyglucose) uptake on positron emission tomography (PET) in lung cancer and to examine the similarities and differences between them.

Methods

A total of 34 patients with resected primary lung cancers were investigated in this study. There were 17 adenocarcinomas, 12 squamous cell carcinomas, and 5 cancers of other cell types. Immunohistochemical Glut1 intensity was categorized into three groups: negative, positive, and strongly positive. Glut1 frequency was defined by the proportion of positive cells among all cancer cells, and it was graded on a semiquantitative scale as 0-100% in 10% increments. The data are expressed as the mean +/-SD.

Results

Maximum standardized uptake values (SUVmax) were 4.8 +/-6.3 in "negative" Glut1 intensity cases, 4.7 +/-3.1 in "positive" Glut1 intensity cases, and 11.2 +/-5.2 in "strongly positive" Glut1 intensity cases. Although SUVmax correlated significantly with tumor size (correlation coefficient 0.58, P = 0.00033), Glut1 frequency did not correlate significantly with tumor size (correlation coefficient 0.18, P = 0.301). Cell type and cell differentiation correlated significantly with Glut1 expression and (18)F-FDG uptake.

Conclusion

Glut1 expression correlates significantly with (18)F-FDG uptake. There are similarities in cell differentiation and cell type between Glut1 expression and (18)F-FDG uptake. (18)F-FDG uptake correlates significantly with tumor size, but Glut1 expression does not."xsd:string
http://purl.uniprot.org/citations/20703861http://purl.org/dc/terms/identifier"doi:10.1007/s11748-010-0603-1"xsd:string
http://purl.uniprot.org/citations/20703861http://purl.uniprot.org/core/author"Machida Y."xsd:string
http://purl.uniprot.org/citations/20703861http://purl.uniprot.org/core/author"Ueda Y."xsd:string
http://purl.uniprot.org/citations/20703861http://purl.uniprot.org/core/author"Tanaka M."xsd:string
http://purl.uniprot.org/citations/20703861http://purl.uniprot.org/core/author"Ueno M."xsd:string
http://purl.uniprot.org/citations/20703861http://purl.uniprot.org/core/author"Sakuma T."xsd:string
http://purl.uniprot.org/citations/20703861http://purl.uniprot.org/core/author"Higashi K."xsd:string
http://purl.uniprot.org/citations/20703861http://purl.uniprot.org/core/author"Zhao X.T."xsd:string
http://purl.uniprot.org/citations/20703861http://purl.uniprot.org/core/author"Usuda K."xsd:string
http://purl.uniprot.org/citations/20703861http://purl.uniprot.org/core/author"Sagawa M."xsd:string
http://purl.uniprot.org/citations/20703861http://purl.uniprot.org/core/author"Aikawa H."xsd:string
http://purl.uniprot.org/citations/20703861http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20703861http://purl.uniprot.org/core/name"Gen Thorac Cardiovasc Surg"xsd:string
http://purl.uniprot.org/citations/20703861http://purl.uniprot.org/core/pages"405-410"xsd:string
http://purl.uniprot.org/citations/20703861http://purl.uniprot.org/core/title"Correlation between glucose transporter-1 expression and 18F-fluoro-2-deoxyglucose uptake on positron emission tomography in lung cancer."xsd:string
http://purl.uniprot.org/citations/20703861http://purl.uniprot.org/core/volume"58"xsd:string
http://purl.uniprot.org/citations/20703861http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20703861
http://purl.uniprot.org/citations/20703861http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20703861
http://purl.uniprot.org/uniprot/#_P11166-mappedCitation-20703861http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20703861
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