| http://purl.uniprot.org/citations/20708158 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20708158 | http://www.w3.org/2000/01/rdf-schema#comment | "Two vascular growth factor families, VEGF and the angiopoietins, play critical and coordinate roles in tumor progression and metastasis. A single inhibitor targeting both VEGF and angiopoietins is not available. Here, we developed a chimeric decoy receptor, namely double anti-angiogenic protein (DAAP), which can simultaneously bind VEGF-A and angiopoietins, blocking their actions. Compared to VEGF-Trap or Tie2-Fc, which block either VEGF-A or angiopoietins alone, we believe DAAP is a highly effective molecule for regressing tumor angiogenesis and metastasis in implanted and spontaneous solid tumors; it can also effectively reduce ascites formation and vascular leakage in an ovarian carcinoma model. Thus, simultaneous blockade of VEGF-A and angiopoietins with DAAP is an effective therapeutic strategy for blocking tumor angiogenesis, metastasis, and vascular leakage."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2010.07.001"xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Kim M."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Lee G.M."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Jung K."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Yoo O.J."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Lee J.E."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Nagy A."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Koh G.Y."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Kim H.Z."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Lim N.K."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Nam D.H."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Jeon B.H."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Kim K.E."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Sung H.K."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Jeon C.J."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Koh Y.J."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Hwang S.I."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/author | "Oh N."xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/pages | "171-184"xsd:string |
| http://purl.uniprot.org/citations/20708158 | http://purl.uniprot.org/core/title | "Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage."xsd:string |