| http://purl.uniprot.org/citations/20713520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20713520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20713520 | http://www.w3.org/2000/01/rdf-schema#comment | "Eukaryotic translation initiation begins with ribosomal recruitment of aminoacylated initiator tRNA (Met-tRNA(Met)(i)) by eukaryotic initiation factor eIF2. In cooperation with eIF3, eIF1, and eIF1A, Met-tRNA(Met)(i)/eIF2/GTP binds to 40S subunits yielding 43S preinitiation complexes that attach to the 5'-terminal region of mRNAs and then scan to the initiation codon to form 48S initiation complexes with established codon-anticodon base-pairing. Stress-activated phosphorylation of eIF2alpha reduces the level of active eIF2, globally inhibiting translation. However, translation of several viral mRNAs, including Sindbis virus (SV) 26S mRNA and mRNAs containing hepatitis C virus (HCV)-like IRESs, is wholly or partially resistant to inhibition by eIF2 phosphorylation, despite requiring Met-tRNA(Met)(i). Here we report the identification of related proteins that individually (Ligatin) or together (the oncogene MCT-1 and DENR, which are homologous to N-terminal and C-terminal regions of Ligatin, respectively) promote efficient eIF2-independent recruitment of Met-tRNA(Met)(i) to 40S/mRNA complexes, if attachment of 40S subunits to the mRNA places the initiation codon directly in the P site, as on HCV-like IRESs and, as we show here, SV 26S mRNA. In addition to their role in initiation, Ligatin and MCT-1/DENR can promote release of deacylated tRNA and mRNA from recycled 40S subunits after ABCE1-mediated dissociation of post-termination ribosomes."xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1957510"xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1957510"xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/author | "Hellen C.U."xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/author | "Hellen C.U."xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/author | "Pestova T.V."xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/author | "Pestova T.V."xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/author | "Skabkin M.A."xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/author | "Skabkin M.A."xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/author | "Skabkina O.V."xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/author | "Skabkina O.V."xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/author | "Komar A.A."xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/author | "Komar A.A."xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/author | "Dhote V."xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/author | "Dhote V."xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/pages | "1787-1801"xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/pages | "1787-1801"xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/title | "Activities of ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling."xsd:string |
| http://purl.uniprot.org/citations/20713520 | http://purl.uniprot.org/core/title | "Activities of ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling."xsd:string |