| http://purl.uniprot.org/citations/20714347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20714347 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms by which ethanol and inhaled anesthetics influence the nervous system are poorly understood. Here we describe the positional cloning and characterization of a new mouse mutation isolated in an N-ethyl-N-nitrosourea (ENU) forward mutagenesis screen for animals with enhanced locomotor activity. This allele, Lightweight (Lwt), disrupts the homolog of the Caenorhabditis elegans (C. elegans) unc-79 gene. While Lwt/Lwt homozygotes are perinatal lethal, Lightweight heterozygotes are dramatically hypersensitive to acute ethanol exposure. Experiments in C. elegans demonstrate a conserved hypersensitivity to ethanol in unc-79 mutants and extend this observation to the related unc-80 mutant and nca-1;nca-2 double mutants. Lightweight heterozygotes also exhibit an altered response to the anesthetic isoflurane, reminiscent of unc-79 invertebrate mutant phenotypes. Consistent with our initial mapping results, Lightweight heterozygotes are mildly hyperactive when exposed to a novel environment and are smaller than wild-type animals. In addition, Lightweight heterozygotes exhibit increased food consumption yet have a leaner body composition. Interestingly, Lightweight heterozygotes voluntarily consume more ethanol than wild-type littermates. The acute hypersensitivity to and increased voluntary consumption of ethanol observed in Lightweight heterozygous mice in combination with the observed hypersensitivity to ethanol in C. elegans unc-79, unc-80, and nca-1;nca-2 double mutants suggests a novel conserved pathway that might influence alcohol-related behaviors in humans."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1001057"xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/author | "Liao M."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/author | "Peterson A.S."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/author | "Speed T.P."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/author | "Medrano J.F."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/author | "McIntire S.L."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/author | "Sonner J.M."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/author | "Ashique A.M."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/author | "Speca D.J."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/author | "Bowers M.S."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/author | "Chihara D."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/author | "Pierce-Shimomura J.T."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/author | "Eger E.I."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/author | "Rabbee N."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/author | "Chitwood J."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/author | "Gularte R.J."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/pages | "e1001057"xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/title | "Conserved role of unc-79 in ethanol responses in lightweight mutant mice."xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/20714347 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20714347 |