| http://purl.uniprot.org/citations/20715101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20715101 | http://www.w3.org/2000/01/rdf-schema#comment | "The HER2 oncogene is frequently over-expressed in human cancers and a promising target for immune therapy. Previous studies have shown that over-expression of mouse or rat HER2 leads to markedly reduced levels of major histocompatibility complex (MHC) class I and molecules of the antigen processing and presentation machinery (APM), thus resulting in a phenotype promoting tumor escape from the immune system. Our study focuses on analyzing the effect of HER2 on MHC class I antigen presentation and sensitivity to tumor-antigen specific cytotoxic T lymphocytes (CTLs) in HLA-A2.1(+) melanoma cell lines. We demonstrate significant inverse correlations both between the expression of HER2 and total MHC class I surface expression as well as between HER2 and HLA-A2. A significant reduction of HLA-A2 levels was found when melanoma and carcinoma cell lines were transfected with a human HER2 gene. A signaling-competent HER2 molecule was crucial for the observed HLA-A2 down-regulation, as transfectants expressing high levels of HER2 mutated in the tyrosine signaling domain did not show altered HLA-A2 expression. Importantly, the human melanoma cell line EST049 demonstrated reduced HER2 and melanoma antigen-specific recognition by CTLs upon HER2 transfection. In addition, high expression of HER2 prevented both IFN-γ mediated HLA-A2 up-regulation and improved recognition by HLA-A2-restricted CTLs in treated cells. Moreover, key APM molecules were down-regulated by HER2. These findings implicate that HER2 over-expressing tumors may be more prone to escape from HLA-A2 restricted CTLs suggesting that immunotherapy approaches inducing an integrated humoral, cellular and innate immune response would be most effective."xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.25613"xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/author | "Ando T."xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/author | "Seliger B."xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/author | "Nishimura M.I."xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/author | "Mimura K."xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/author | "Mougiakakos D."xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/author | "Choudhury A."xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/author | "Okita R."xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/author | "Kiessling R."xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/author | "Ichikawa J."xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/author | "Johansson C.C."xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/author | "Krug N."xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/author | "Poschke I."xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/author | "Handke D."xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/pages | "390-401"xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/title | "T cell recognition of HLA-A2 restricted tumor antigens is impaired by the oncogene HER2."xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/20715101 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20715101 |
| http://purl.uniprot.org/citations/20715101 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20715101 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-20715101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20715101 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-20715101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20715101 |