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http://purl.uniprot.org/citations/20715157http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20715157http://www.w3.org/2000/01/rdf-schema#comment"

Background

CYP3A enzymes, due to their role in the metabolism of steroid hormones, are suggested to affect carcinogenesis of hormone-related cancers. The purpose of the present study was to evaluate the association between polymorphisms located in CYP3A43, breast cancer risk, and tumor characteristics.

Methods

A 3-plex matrix-assisted laser desorption ionization time of flight mass spectrometry assay has been established for CYP3A43_74_delA (CYP3A43*2A), CYP3A43_1018_C>G (CYP3A43*3), and CYP3A43_1047_C>T (CYP3A43*1B) polymorphisms, and 1021 breast cancer cases and 1015 age-matched, population-based controls from the German GENICA collection have been genotyped.

Results

No differences in genotype frequencies between cases and controls were observed, indicating that CYP3A43_74_delA is not associated with breast cancer risk. Subgroup analyses showed an association between the CYP3A43_74_delA allele and high-grade tumors (odds ratio, 1.74; 95% confidence interval, 1.14-2.65 [P=.010 and Ptrend=.012]).

Conclusions

The data support the notion that the CYP3A43_74_delA variant may result in decreased protein and/or activity levels, and this may further lead to increased hormone levels to promote tumor cell growth and hinder differentiation."xsd:string
http://purl.uniprot.org/citations/20715157http://purl.org/dc/terms/identifier"doi:10.1002/cncr.25508"xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Haas S."xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Winter S."xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Brauch H."xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Hamann U."xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Justenhoven C."xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Ko Y.D."xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Bruning T."xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Fischer H.P."xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Baisch C."xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Harth V."xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Pesch B."xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Rabstein S."xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Brauch H.'"xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Justenhoven C.'"xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Hamann U.'"xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Bruning T.'"xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Fischer H.P.'"xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Haas S.'"xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Ko Y.D.'"xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/author"Pesch B.'"xsd:string
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20715157http://purl.uniprot.org/core/name"Cancer"xsd:string
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