Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/20718347http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20718347http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the association between HLA-DQA1 gene polymorphism and the outcomes of hepatitis B virus infection in Chinese Han population.

Methods

A total of 180 consecutive patients with biopsy-proven hepatitis B virus infection (120 patients with chronic hepatitis B and 60 patients with asymptomatic HBV carrier) and 60 subjects who resolved from HBV infection spontaneously were studied. Genotype of human leukocyte antigen(HLA)-DQA1 was detected by polymerase chain reaction sequence specific primer(PCR-SSP).

Results

(1) The frequency of HLA-DQA1 * 0201 allele in chronic hepatitis B group was significant higher than the frequency in resolved from HBV infection spontaneously group (38.3% vs. 5.8%, P < 0.001, A = 10.04, 95% CI: 4.48-22.48). The frequency of HLA-DQA1 * 0102 allele in chronic hepatitis B group was significant lower than the frequency in resolved from HBV infection spontaneously group (9.6% vs. 36.7%, P < 0.001, A = 0.183, 95% CI: 0.10-0.32). (2) The frequency of HLA-DQA1 * 0201 allele in chronic hepatitis B group was significant higher than the frequency in asymptomatic HBV carrier group (38.3% vs. 7.5%, P < 0.01, A = 7.667, 95% CI:3.7-15.87). The frequency of HLA-DQA1 * 0102 allele in chronic hepatitis B group was significant lower than the frequency in asymptomatic HBV carrier group (20% vs. 9.6%, P < 0.01, A = 0.424, 95% CI: 0.23-0.79).

Conclusion

HLA-DQA1 gene polymorphism may play an important role in the outcomes of hepatitis B virus infection in-Chinese Han population. The HLA-DQA1 * 0102 allele could keep individuals away from HBV infection, and HLA-DQA1 * 0201 allele could aggravate persistant infection of HBV and hepatic inflammatory."xsd:string
http://purl.uniprot.org/citations/20718347http://purl.uniprot.org/core/author"Liu C.L."xsd:string
http://purl.uniprot.org/citations/20718347http://purl.uniprot.org/core/author"Guo J.C."xsd:string
http://purl.uniprot.org/citations/20718347http://purl.uniprot.org/core/author"Shi W.Z."xsd:string
http://purl.uniprot.org/citations/20718347http://purl.uniprot.org/core/author"Shi J.P."xsd:string
http://purl.uniprot.org/citations/20718347http://purl.uniprot.org/core/author"Xun Y.H."xsd:string
http://purl.uniprot.org/citations/20718347http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/20718347http://purl.uniprot.org/core/name"Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/20718347http://purl.uniprot.org/core/pages"430-433"xsd:string
http://purl.uniprot.org/citations/20718347http://purl.uniprot.org/core/title"[Association between HLA-DQA1 gene polymorphism and the outcomes of hepatitis B virus infection]."xsd:string
http://purl.uniprot.org/citations/20718347http://purl.uniprot.org/core/volume"23"xsd:string
http://purl.uniprot.org/citations/20718347http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20718347
http://purl.uniprot.org/citations/20718347http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20718347
http://purl.uniprot.org/uniprot/#_A0A141R7F8-mappedCitation-20718347http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20718347
http://purl.uniprot.org/uniprot/#_D0V3Q3-mappedCitation-20718347http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20718347
http://purl.uniprot.org/uniprot/#_A0A0C7DW92-mappedCitation-20718347http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20718347
http://purl.uniprot.org/uniprot/#_A0A2U7NN70-mappedCitation-20718347http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20718347
http://purl.uniprot.org/uniprot/#_Q14K62-mappedCitation-20718347http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20718347
http://purl.uniprot.org/uniprot/#_Q14K63-mappedCitation-20718347http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20718347
http://purl.uniprot.org/uniprot/#_Q14K64-mappedCitation-20718347http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20718347
http://purl.uniprot.org/uniprot/#_A0A2K9UYT9-mappedCitation-20718347http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20718347
http://purl.uniprot.org/uniprot/#_A0A2K9UYU0-mappedCitation-20718347http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20718347
http://purl.uniprot.org/uniprot/#_A0A7D5HAT0-mappedCitation-20718347http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20718347
http://purl.uniprot.org/uniprot/#_A0A7G8KPP6-mappedCitation-20718347http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20718347
▶